Developed in our previous study, this model combines druglikeness
evaluation, oral bioavailability prediction, multiple drug targets prediction as well as network pharmacology techniques.
The Osiris Property Explorer calculated the druglikeness
and drug-score characteristics based in the list of all available fragments from 3300 traded drugs as well as 15,000 commercially available chemicals (Fluka, Germany).
The above five molecules are toxic free and can bind with PAI1, but the bioactivities of the compounds revealed that 2-(acetylamino)-2-deoxy-A-D-glucopyranose and alpha-L-fucose are having the property of druglikeness
at moderate level; the rest cannot be used for the purpose of drug.