This project will uncover the spatiotemporal dynamics of hfscs fate decisions and establish the role of the niche in this process (aim1), Decipher key gene-regulatory networks and epigenetic barriers that control phenotypic plasticity (aim2), And discover druggable
signaling networks that drive bi-directional reprogramming of hfscs and their progeny (aim3).
The company said its clinical programe is focused on three druggable
intervention points with potential to improve safety and efficacy of current AML combination therapies, around which it has robust IP and substantial freedom to operate: RASP-101, an established anticancer therapeutic for treating nucleophosmin (NPM1) mutated acute myeloid leukemia (AML); RASP-201, an inhibitor of lysine specific histone demethylase 1 (LSD1 or KDM1A), which is overexpressed in several human cancers including AML plays an important role in epigenetic modification that contributes to cellular proliferation; and, RASP-301, high affinity, NPM1 binding molecules exhibiting selective cytotoxic activity on AML cells.
The search for druggable
genomic lesions has led to a number of clinical trials where genomic analyses were fused with the use of various targeted therapies.
Chair of the Pulmonary Department at The University of Texas MD Anderson Cancer Center, are targeting a key molecule of this pathway as a druggable
target that can be modulated to reduce hypersecretion of mucus.
This technique provides a quantitative read out of the actual genetic program occurring in the cancer cells, which allowed us to uncover relevant molecular mechanisms cooperating to promote tumorigenesis, and to identify possible druggable
It is the ultimate goal of Insight Genetics to develop a robust sequencing strategy to extensively profile the TNBC subtypes and identify druggable
targets and biomarkers predictive of responsiveness to various therapies.
Having all three papers come out at about the same time is encouraging because it means that KRAS is druggable
if you use outside-the-box methods," Pecot said.
targets should be amenable to high throughput screening, in silico analyses and other drug discovery methodologies, which in turn, will lead to innovative therapies.
That exercise would still ignore the costs of conducting basic research, and conducting the laboratory, preclinical, and clinical testing on potentially druggable
compounds that did not become commercial products.
We thought PDGFR-B might be a druggable
target in these FOXC2-expressing cells," Mani said.
In other words, there is a large gap between what we are attacking (called druggable
molecules) and what we might be attacking (undruggable) with drugs made to react with a certain portion of a particular molecule.
Aureus Sciences has built its new web portal around its knowledge platform, which analyses, indexes and organises critical chemical and bioactivity information of the druggable
genome into best-in-class scientific databases for use by researchers involved in the drug discovery process.