is often maintained on rather lean schedules of reinforcement.
This gives us a possible mechanism for how drug use fuels further drug-seeking behavior
, said principal investigator Linda Wilbrecht, PhD, a Gallo investigator now at UC Berkeley, but who led the research while she was on the UCSF faculty.
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior
Until quite recently, in all likelihood the focus would have been on the need to defend the integrity of health care institutions and professionals from patients with addiction disorders and drug-seeking behaviors
, as well as protecting such patients from their own self-destructive impulses.
The problem of drug-seeking behavior
was explained in graphic terms by a member of the audience at the NIDA conference panel on prescription drugs.
I have seen an instance where identical twins, one of each, are being cared for by their two grandmothers because both parents are engaged in drug-seeking behavior
Removing the dependence category should help clinicians better differentiate between compulsive drug-seeking behavior
, and the normal responses of tolerance and withdrawal when using prescribed medications, according to members of the DSM-5 Task Force.
Dopamine, a chemical messenger in the brain, mediates internal rewards and is involved in an addict's drug-seeking behavior
Troisi, in press) may model how interoceptive changes in the nervous system previously correlated with reinforcement, even drug reinforcement, can be extinguished, thereby decreasing the likelihood of relapse of drug-seeking behavior
and drug self-administration.
The authors of the new study seem unaware of the fact that cocaine use peaked long after smoking rates had come down, exactly the opposite of what they predict, and that drug-seeking behavior
in the real world is not at all similar to mouse neurobiology," observed Phillips.
and colleagues that found that active psychosocial criteria, including depression, evidence of coercion, and drug-seeking behavior
that led to donor exclusion was more common in donor candidates under age 30 years.
Results from laboratory studies indicate that animals return to drug-seeking behavior
when they experience stress and other stimuli similar to those that send people back to drugs.