drug-induced liver injury


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drug-induced liver injury

Abbreviation: DILI.
Hepatic inflammation, hepatocellular necrosis, or jaundice due to exposure to a medication or toxin. The most common cause of DILI is an overdose of acetaminophen, but many other medications can damage liver cells and produce signs, symptoms, and laboratory findings suggestive of cholestasis or hepatitis.
See also: injury
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Drug-induced liver injury in the United States: A review of multi-ingredient supplements.
Model for end-stage liver disease score as a predictor of short-term outcome in patients with drug-induced liver injury. Scand J Gastroenterol 2015; 50: 439-46.
Bonkovsky et al., "Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States," Gastroenterology, vol.
Tong, "A Model to predict severity of drug-induced liver injury in humans," Hepatology, vol.
Lucena, "Drug-induced liver injury: Interactions between drug properties and host factors," Journal of Hepatology, vol.
The symptoms of drug-induced liver injury can vary and may include jaundice, nausea, fatigue, and gastrointestinal discomfort.
DILIsym Services provides drug-induced liver injury simulation software and related consulting services to the pharmaceutical industry.
In a large retrospective analysis from Ankara, antibiotics were the most common causative agents in 84 of 170 patients with drug-induced liver injury (Dag et al.
Stern, "Drug-induced liver injury associated with the use of nonnucleoside reverse-transcriptase inhibitors," Clinical Infectious Diseases, vol.
MgIG also showed hepatoprotective effects in drug-induced liver injury [13,14], immune-mediated liver injury [10], and fatty liver [15].
According to the Drug-Induced Liver Injury Network (DILIN), causes of acute liver failure (ALF) from herbal supplements have increased from 7% to 20% over their study period from 2007 to 2013 [3].

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