drug-drug interaction


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interaction

(int?er-ak'shon) [ inter- + action]
Alternating, reciprocating, or mutual influence or effect.

dielectric interaction

Determination of the quantity of the electrical polarity or dipole moment of a molecule.
See: dipole

drug interaction

, drug-drug interaction
The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases. It is important for the patient, pharmacist, physician, and nurse to be aware of the potential interaction of drugs that are prescribed as well as those that the patient may be self-administering.

Many patients, esp. the elderly, may take several medicines each day. The chances of developing an undesired drug interaction increase rapidly with the number of drugs used.

food and drug interactions

The effect of nutrients on the absorption, distribution, metabolism or excretion of medications. For example, alkaloids in potatoes may influence the effects of anesthetics; excess intake of vegetables rich in vitamin K may interfere with the action of anticoagulants; prolonged use of antacids may cause phosphate depletion; consumption of grapefruits or grapefruit juice may influence the half-life of some antiretroviral drugs.

patient-ventilator interaction

The complex link between a patient's neurologically mediated control of breathing (and the elasticity and resistance of his or her airways) and the pressures and volumes of gases injected into the patient by a mechanical ventilator.
See: patient-ventilator dyssynchrony

photoelectric interaction

The absorption of a photon by matter from its source of emission, producing a photoelectron and a K shell vacancy. The K shell vacancy is then filled by a cascade of electrons, each of which produces a characteristic photon. In clinical radiology, photoelectric absorption causes image contrast and increases the patient's exposure to scattered radiation.

drug interaction

, drug-drug interaction
The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases. It is important for the patient, pharmacist, physician, and nurse to be aware of the potential interaction of drugs that are prescribed as well as those that the patient may be self-administering.

Many patients, esp. the elderly, may take several medicines each day. The chances of developing an undesired drug interaction increase rapidly with the number of drugs used.

See also: interaction
References in periodicals archive ?
Significant drug-drug interactions were more and mostly caused by Pharmacodynamic mechanism.
As the elderly patients are more likely to receive multiple medications, potential drug-drug interactions are more likely in this population.
The unknown drug-drug interactions are categorized in such a group because, some of the medications were not available in the database of the interactions checker and such prescriptions were categorized as prescriptions which contain unknown drug-drug interactions.
Practioners' views on computerized drug-drug interaction alerts in the VA system.
The study team used a software program (Lexi-Comp DDI) to find all drug-drug interactions for each person.
The company has initiated a phase 1 drug-drug interaction and safety study in healthy volunteers, designed to evaluate the potential for maribavir to affect the blood levels of various other drugs that are metabolized by the liver.
The drug-drug interaction caused by PXR in humans may also be dangerous, he said.
"EDI is the most comprehensive resource available for drug interaction information." First DataBank's Drug-Drug Interaction Module (DDIM(tm)) -- clinically reviewed drug interaction information for integration into healthcare information systems -- provides page references exclusively to EDI so pharmacists can quickly refer to more in-depth drug interaction information.
Patients taking pirfenidone will be excluded because of a known drug-drug interaction between pirfenidone and PBI-4050.