drug-drug interaction


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drug-drug interaction

a modification of the effect of a drug when administered with another drug. The effect may be an increase or a decrease in the action of either substance, or it may be an adverse effect that is not normally associated with either drug. The particular interaction may be the result of a chemical-physical incompatibility of the two drugs or a change in the rate of absorption or the quantity absorbed in the body, the binding ability of either drug, or an alteration in the ability of receptor sites and cell membranes to bind either drug. Most adverse drug-drug interactions are either pharmacodynamic or pharmacokinetic in nature.

interaction

(int?er-ak'shon) [ inter- + action]
Alternating, reciprocating, or mutual influence or effect.

dielectric interaction

Determination of the quantity of the electrical polarity or dipole moment of a molecule.
See: dipole

drug interaction

, drug-drug interaction
The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases. It is important for the patient, pharmacist, physician, and nurse to be aware of the potential interaction of drugs that are prescribed as well as those that the patient may be self-administering.

Many patients, esp. the elderly, may take several medicines each day. The chances of developing an undesired drug interaction increase rapidly with the number of drugs used.

food and drug interactions

The effect of nutrients on the absorption, distribution, metabolism or excretion of medications. For example, alkaloids in potatoes may influence the effects of anesthetics; excess intake of vegetables rich in vitamin K may interfere with the action of anticoagulants; prolonged use of antacids may cause phosphate depletion; consumption of grapefruits or grapefruit juice may influence the half-life of some antiretroviral drugs.

patient-ventilator interaction

The complex link between a patient's neurologically mediated control of breathing (and the elasticity and resistance of his or her airways) and the pressures and volumes of gases injected into the patient by a mechanical ventilator.
See: patient-ventilator dyssynchrony

photoelectric interaction

The absorption of a photon by matter from its source of emission, producing a photoelectron and a K shell vacancy. The K shell vacancy is then filled by a cascade of electrons, each of which produces a characteristic photon. In clinical radiology, photoelectric absorption causes image contrast and increases the patient's exposure to scattered radiation.

drug interaction

, drug-drug interaction
The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases. It is important for the patient, pharmacist, physician, and nurse to be aware of the potential interaction of drugs that are prescribed as well as those that the patient may be self-administering.

Many patients, esp. the elderly, may take several medicines each day. The chances of developing an undesired drug interaction increase rapidly with the number of drugs used.

See also: interaction
References in periodicals archive ?
Drug-drug interactions fall into 2 categories: pharmacodynamic (PD) and pharmacokinetic (PK):
Practioners' views on computerized drug-drug interaction alerts in the VA system.
An important finding is that people starting treatment with the integrase inhibitor Isentress ran a much lower risk of drug-drug interactions than did people starting treatment with a PI (such as Reyataz or Prezista) or an NNRTI (such as Sustiva or Viramune).
Drug-drug interactions are common with medications metabolized through the P450 enzyme system.
Potential drug-drug interactions in 5,125 mostly elderly out-patients in Gothenburg, Sweden.
Aureus Demonstrates New Application for Risk Assessment of Drug-Drug Interactions Involving Multiple Enzymatic Metabolic Pathways at North American Regional ISSX Meeting, October 18-22, 2009, Baltimore
The results demonstrate that CellPort Technologies can help predict the potential for pharmacokinetic drug-drug interactions by examining the activity of specific transport proteins involved in the transport of drug molecules across cell membranes.
The agreement includes close collaboration with Roche scientists to advance the capabilities of GastroPlus in the area of simulating drug-drug interactions.
Drug-drug interactions are a concern for the prescriber because they have the potential for causing untoward outcomes for everyone involved, morbidity and even mortality for the patients, liability for the prescriber and increased costs for the healthcare system.
Complete functional knockouts of transporters in the intestinal cell line (Caco-2) enables identification of critical safety and efficacy characteristics compared to current chemical inhibitor-based assays and more precise determination of a drug candidate's potential drug-drug interactions.
The new drug candidate has the advantage of presenting reduced interaction with drug transporters and metabolizing enzymes responsible for drug-drug interactions, and is thus a suitable component in combination of drugs in a treatment cocktail.