drug tolerance


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Related to drug tolerance: drug withdrawal

tolerance

 [tol´er-ans]
1. the ability to bear something potentially difficult.
2. the ability to endure unusually large doses of a poison or toxin.
3. drug tolerance. adj., adj tol´erant.
acquired drug tolerance drug tolerance.
ambiguity tolerance the ability to withstand conflicting or complex situations without undue psychological stress.
drug tolerance a decreasing response to repeated constant doses of a drug or the need for increasing doses to maintain a constant response. See also drug dependence and habituation.
immunologic tolerance specific nonreactivity of lymphoid tissues to a particular antigen capable under other conditions of inducing immunity.
standing tolerance the amount of time an individual is capable of maintaining an erect, upright position.
tolerance test
1. an exercise test to determine the efficiency of the circulation.
2. a test to determine the body's ability to metabolize a substance or to endure administration of a drug.

drug tolerance

Psychiatry Repeated use of some substance or drug, often narcotics, so that ever larger doses are required to produce the same physiologic and/or psychologic effect obtained previously by a smaller dose.

drug tolerance

A progressive reduction in the effect of a drug, following repeated exposure to it, so that it no longer has the desired effect in the original dose.
References in periodicals archive ?
One interpretation of the role of contextual cues in drug tolerance is based on a Pavlovian conditioning model (Siegel, 1975, 1977, 1989).
Several recent reports have begun to extend the Pavlovian conditioning model of drug tolerance to other forms of homeostatic challenges or stressors (Kissinger & Riccio, 1995; Poulos & Cappell, 1991; Riccio, MacArdy, & Kissinger, 1991), and one such challenge involves the thermoregulatory system.
Using a feature-positive discrimination training, we evaluated the contribution of contexts as occasion setters of the ataxic effect of ethanol in rats The results suggest that the context acquire occasion setter properties of the drug tolerance, and that these properties can be extinguished.
Effects of HMS5552 on Drug Tolerance. The effects of HMS5552 on drug tolerance were studied on days 1 and 27 after i.g.
"A persons drug tolerance can diminish during their time in jail, so the risk of overdose is higher."
Strang was also concerned that addicted remand prisoners who are not offered methadone would see their drug tolerance levels go down, putting them at risk of fatal overdoses when they leave.
"A personEs drug tolerance can diminish during their time in jail, so the risk of overdose is higher."
"A personAaAeAe drug tolerance can diminish during their time in jail, so the risk of overdose is higher."
Any patient who shows drug tolerance to antipsychotics, who needs an increasingly high dose, or who needs dual or triple therapy is a candidate for adjunctive therapy with anticonvulsants, he said.
Figuring out the exact biochemistry behind drug tolerance could lead to new strategies for undermining unusually hardy cancer cells.
He describes the legislation of drug use and trafficking in France and its tradition of central control, the political and social culture that has led to drug tolerance in The Netherlands, and the restrictive alcohol policies in Sweden that have led to the same in the case of drugs, and how these differences have led to conflict at the international level.
Occasion setting and drug tolerance. Integrative Physiological y Behavioral Science, 37, 165-177.