The literature search was aimed to select documents and articles relevant to address questions such as "What are the current Brazilian rules for drug interchangeability or substitutability of prescription drugs at the pharmacies?", " Is there a scientific rationale for making drug products with 'comparable' bioavailability, although not being proven bioequivalent products, interchangeable with each other?", "Are the concerns regarding generic drug substitution
To reduce the price of prescription medications, the World Health Organization (WHO) recommends that generic drug substitution
be a component of every country's National Pharmaceutical Policy (1).
As a result of the latter studies, the American Epilepsy Society rescinded its 2007 position statement opposing generic substitution of anti-epileptic drugs and acknowledged that drug substitution
with FDA-approved generics reduces cost without compromising efficacy.
The effect of introducing rebate contracts to promote generic drug substitution
, on doctors' prescribing practices.
Research on jurisdictions legally regulating production, distribution and use of cannabis suggests that such benefits may include reduction of drug market-related violence, potential reduction of alcohol and illegal substance use through drug substitution
, separation of cannabis from other illegal drug markets, and less criminalization of users.
the Hatch-Waxman regulatory framework, state drug substitution
is allowed in the United States under substitution laws that were passed in 1984.
Switch-backs can be seen as a potential indicator of clinical failure to achieve desired health outcomes from the original brand-to-generic drug substitution
. Like generic substitution, switchbacks are broken down as either bioequivalent (within the same drug molecule, i.e., simvastatin to Zocor[R]) or therapeutic (across different drug molecules, i.e., simvastatin to atorvastatin).
In the preliminary phase, drug substitution
carried out after consulting his physician followed by scaling and root planning.
This incorporates a range of cost-cutting measures, including generic drug substitution
and outlines the procedures regarding the supply of medicines and medical equipment to patients.
The HIV Clinicians Society recently drew up a drug substitution
guideline list, but stockouts leave diabetic or hypertensive patients instantly vulnerable.