drug disposition

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drug disposition

general term for the absorption, distribution, metabolism, and excretion of a drug that has been administered.


setting in place.

disposition curve
the graphic representation of changes in the blood concentration of a drug after administration.
drug disposition
getting a drug into its appropriate position in the body and in an appropriate concentration.
References in periodicals archive ?
The effect of grapefruit juice on drug disposition.
Abbreviations: AUC, area under the time-plasma concentration curve; BCS, biopharmaceutical classification system; BDDCS, biopharmaceutics drug disposition classification system; CYP, cytochrome P450; GTE, green tea extract; EGCG, C-)-epigallocatechi n-3-gal late; OATP, organic anion transporting polypeptide; P-gp, P-glycoprotein.
Busulfan dosing is often optimized through determination of the AUC, which is typically done after the first dose because of the intra- and interpatient variation in drug disposition, as well as the drug's narrow therapeutic interval.
Instead, it simply reports drug disposition after therapy has started and reached steady state.
With a focus on modelling and simulation, Alison will provide attendees with exclusive insight sorrounding key developments in Kadcyla, a HER-2 ADC approved in 2013; PK/PD methodologies for efficacy and safety differentiation; and a proposed mechanistic target mediated drug disposition model.
They then discuss diseases such as autism, depression, Parkinson's disease, stroke, multiple sclerosis, epilepsy, pain, migraine and headaches, fibromyalgia, irritable bowel syndrome, coronary heart disease, cancer, diabetes, obesity, pituitary and thyroid diseases, bone metabolic disorders, adrenal disorders, transsexualism, lupus, rheumatoid arthritis, gout, HIV, malaria, measles, tuberculosis, sexual dysfunction, chronic kidney disease, and dementia, as well as policies and practices regarding women in clinical drug trials, drug disposition and effect, aging, and cognition.
joined Lilly Research Laboratories in 2000 as Senior Director of Drug Disposition with a primary focus on ADME, metabolism and bioanalytical capabilities in support of the development and discovery of LRUs molecule portfolio.
1997) Genetic and environmental factors affecting drug disposition in man.
First she discusses drug disposition and effects of drugs on the body.

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