Abbreviations: AUC, area under the time-plasma concentration curve; BCS, biopharmaceutical classification system; BDDCS, biopharmaceutics drug disposition
classification system; CYP, cytochrome P450; GTE, green tea extract; EGCG, C-)-epigallocatechi n-3-gal late; OATP, organic anion transporting polypeptide; P-gp, P-glycoprotein.
Busulfan dosing is often optimized through determination of the AUC, which is typically done after the first dose because of the intra- and interpatient variation in drug disposition
, as well as the drug's narrow therapeutic interval.
They then discuss diseases such as autism, depression, Parkinson's disease, stroke, multiple sclerosis, epilepsy, pain, migraine and headaches, fibromyalgia, irritable bowel syndrome, coronary heart disease, cancer, diabetes, obesity, pituitary and thyroid diseases, bone metabolic disorders, adrenal disorders, transsexualism, lupus, rheumatoid arthritis, gout, HIV, malaria, measles, tuberculosis, sexual dysfunction, chronic kidney disease, and dementia, as well as policies and practices regarding women in clinical drug trials, drug disposition
and effect, aging, and cognition.