doxorubicin


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doxorubicin

 [dok″so-roo´bĭ-sin]
an antitumor antibiotic that binds to DNA, inhibits synthesis of nucleic acids, and inhibits cell division. It has one of the widest spectrums of antitumor activity of any antineoplastic agent and is administered intravenously as the hydrochloride salt. Side effects include bone marrow depression, alopecia, and cardiac toxicity; electroencephalogram monitoring is required during its administration. A liposome-encapsulated preparation of the hydrochloride salt is used in the treatment of Kaposi's sarcoma associated with acquired immunodeficiency syndrome (AIDS).

dox·o·ru·bi·cin

(doks'ō-rū'bi-sin),
An antineoplastic antibiotic isolated from Streptomyces peucetius; also used in cytogenetics to produce Q-type chromosome bands.
Synonym(s): adriamycin

doxorubicin

(dŏk′sə-ro͞o′bĭ-sĭn)
n.
An antibiotic obtained from the bacterium Streptomyces peuceticus, used as an anticancer drug.

ABDIC

A "salvage" chemotherapy regimen used for patients who have a disease—e.g., lymphoma—relapse after radiation therapy or chemotherapy.

doxorubicin

Adriamycin Oncology An anthracycline antibiotic used for leukemias, lymphomas, sarcomas, solid tumors Adverse effects BM suppression, alopecia, vomiting, stomatitis, dose-dependent cardiomyopathy. See Chemotherapy.

dox·o·ru·bi·cin

(doks'ō-rū'bi-sin)
An antineoplastic antibiotic isolated from Streptomyces peucetius; also used in cytogenetics to produce Q-type chromosome bands.
Synonym(s): adriamycin.

doxorubicin

An antibiotic, also known as Adriamycin, that interferes with the synthesis of DNA and is thus useful an an anticancer agent. It has many side effects including loss of hair, sickness and vomiting, interference with blood production and heart damage. The drug is on the WHO official list. A brand name is Caelyx.
References in periodicals archive ?
The global Liposomal Doxorubicin Market is projected to witness a higher CAGR during the forecast period.
To prepare ligand for docking calculations, first, the most stable conformation of Doxorubicin was generated from the result of the molecular dynamic calculation, and then was prepared to optimization by the Lig Prep tool in the Maestro 11.4 version of the Schrodinger Software program using the OPLS force field (24).
Doxorubicin administration in the mice Group B resulted in a significant increase in IL2 as compared to Group A.
Nanosecond-pulsed laser-triggered doxorubicin release was tested with different laser pulse numbers and influence (Figure 2(b)).
Patients who received AI had the longest PFS (15.4 months), with a trend toward statistical significance when compared to patients who received doxorubicin alone or in combination with a 2nd agent or platinum-based regimens.
Decreased cardiotoxicity of GPX-150 compared to doxorubicin and other anthracyclines has been demonstrated in preclinical studies and several early clinical studies, supporting the safety and efficacy of GPX-150, the company said.
Co-administration of vitamin C with doxorubicin significantly reduced (p<0.001) the seminiferous epithelial damage compared to doxorubicin group.
The cells were seeded on the substrates at 2.2 x [10.sup.5] cells/[cm.sup.2] and treated with doxorubicin (DOXO; 1 [micro]g/mL) after incubation for 24 h.
Oberley, "Mitochondrial and nuclear p53 localization in cardiomyocytes: redox modulation by doxorubicin (Adriamycin)?," Antioxidants & Redox Signaling, vol.
Cells were treated by doxorubicin 14 [micro]g/ml and control without treatment conducted as previous steps.
Animals in group G2 received 1mg/kg of doxorubicin twice a week for six weeks, and animals in group G1 received only saline solution twice a week for six weeks.