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a synthetic analogue of vitamin D2, used to reduce levels of circulating parathyroid hormone in treatment of secondary hyperparathyroidism associated with chronic renal failure; administered orally or intravenously.


(dox-er-kal-sif-e-role) ,


(trade name),

vitamin D2

(trade name)


Therapeutic: vitamins
Pharmacologic: fat soluble vitamins
Pregnancy Category: B


Treatment of secondary hyperparathyroidism in patients undergoing chronic renal dialysis (IV and PO).Treatment of secondary hyperparathyroidism in patients with Stage 3 or 4 chronic kidney disease (PO only).


Requires activation in the liver to create the active form of vitamin D2.
Promotes the absorption of calcium and decreases parathyroid hormone concentrations.

Therapeutic effects

Treatment and prevention of deficiency states, particularly bone manifestations.
Improved calcium and phosphorous homeostasis in patients with chronic kidney disease.


Absorption: IV administration results in complete bioavailability; well absorbed following oral administration.
Distribution: Unknown.
Metabolism and Excretion: Converted by the liver to the active form of vitamin D2.
Half-life: 32–37 hr (up to 96 hr).

Time/action profile (effects on serum calcium)

POunknown8 wk1 wk
IVunknown8 wk1 wk


Contraindicated in: Hypersensitivity; Hypercalcemia; Vitamin D toxicity; Lactation: Lactation; Concurrent use of magnesium-containing antacids or other vitamin D supplements.
Use Cautiously in: Patients receiving digoxin; Obstetric: Safety not established.

Adverse Reactions/Side Effects

Seen primarily as manifestations of toxicity (hypercalcemia)

Central nervous system

  • dizziness (most frequent)
  • headache (most frequent)
  • malaise (most frequent)
  • somnolence
  • weakness

Ear, Eye, Nose, Throat

  • conjunctivitis
  • photophobia
  • rhinorrhea


  • dyspnea (most frequent)


  • edema (most frequent)
  • arrhythmias
  • bradycardia
  • hypertension


  • nausea (most frequent)
  • vomiting (most frequent)
  • anorexia
  • constipation
  • dry mouth
  • ↑ liver enzymes
  • metallic taste
  • pancreatitis (life-threatening)
  • polydipsia
  • weight loss


  • albuminuria
  • azotemia
  • ↓ libido
  • nocturia
  • polyuria


  • pruritus

Fluid and Electrolyte

  • hypercalcemia


  • hyperthermia


  • arthralgia
  • bone pain
  • metastatic calcification
  • muscle pain


Drug-Drug interaction

Cholestyramine, colestipol, or mineral oil ↓ absorption of vitamin D analogues.Use with thiazide diuretics may result in hypercalcemia.Corticosteroids ↓ effectiveness of vitamin D analogues.Use with digoxin ↑ risk of arrhythmias.Concurrent use of magnesium-containing drugs may lead to hypermagnesemia.Calcium-containing drugs may ↑ risk of hypercalcemia.Concurrent use of other Vitamin D supplements (↑ risk of hypercalcemia).Agents that induce liver enzymes (phenobarbital, rifampin ) and agents that inhibit liver enzymes (atazanavir, clarithromycin, erythromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, verapamil, voriconazole ) may alter requirements for doxercalciferol (monitoring of calcium and phosphorus recommended).Ingestion of foods high in calcium content (see ) may lead to hypercalcemia.


Oral (Adults) Dialysis patients—10 mcg 3 times weekly (at dialysis); dose may be adjusted by 2.5 mcg at 8-wk intervals based on intact PTH concentrations (maximum dose = 20 mcg 3 times weekly). Non-dialysis patients—1 mcg/day; dose may be adjusted by 0.5 mcg at 2–wk intervals based on intact PTH concentrations (maximum dose = 3.5 mcg/day).
Intravenous (Adults) 4 mcg 3 times weekly at the end of dialysis; dose may be adjusted by 1–2 mcg at 8-wk intervals based on intact PTH concentrations (maximum dose = 6 mcg 3 times weekly).

Availability (generic available)

Capsules: 0.5 mcg, 1 mcg, 2.5 mcg
Injection: 2 mcg/mL

Nursing implications

Nursing assessment

  • Assess for symptoms of vitamin deficiency prior to and periodically during therapy.
  • Assess patient for bone pain and weakness prior to and during therapy.
  • Observe patient carefully for evidence of hypocalcemia (paresthesia, muscle twitching, laryngospasm, colic, cardiac arrhythmias, and Chvostek’s or Trousseau’s sign). Protect symptomatic patient by raising and padding side rails; keep bed in low position.
  • Lab Test Considerations: Monitor serum ionized calcium, phosphorus, and intact PTH concentrations prior to initiation of therapy and then weekly during the first 12 wk of therapy. Following this, these labs can be monitored periodically. The serum calcium times phosphorus product (Ca X P) should be maintained at <55 mg2/dL2.
    • Monitor alkaline phosphatase concentration periodically.
  • Toxicity is manifested as hypercalcemia, hypercalciuria, and hyperphosphatemia. Assess patient for appearance of nausea, vomiting, anorexia, weakness, constipation, headache, bone pain, and metallic taste. Later symptoms include polyuria, polydipsia, photophobia, rhinorrhea, pruritus, and cardiac arrhythmias. Notify health care professional immediately if these signs of hypervitaminosis D occur. Treatment usually consists of discontinuation of doxercalciferol, a low-calcium diet, use of low-calcium dialysate in peritoneal dialysis patients, or administration of a laxative. IV hydration and loop diuretics may be ordered to increase urinary excretion of calcium. Hemodialysis may also be used.

Potential Nursing Diagnoses

Imbalanced nutrition: less than body requirements (Indications)


  • Oral: Doses usually given during dialysis sessions.
  • Administer by rapid injection through the catheter at the end of a hemodialysis period.

Patient/Family Teaching

  • Advise patient that medication may be given during their dialysis session.
  • Review diet modifications with patient. See for foods high in calcium and vitamin D. Renal patients must still consider renal failure diet in food selection. Health care professional may order concurrent calcium supplement.
  • Encourage patient to comply with dietary recommendations of health care professional. Explain that the best source of vitamins is a well-balanced diet with foods from the 4 basic food groups and the importance of sunlight exposure. See for foods high in vitamin D.
  • Patients self-medicating with vitamin supplements should be cautioned not to exceed RDA. The effectiveness of megadoses for treatment of various medical conditions is unproved and may cause side effects.
  • Advise patient to avoid concurrent use of antacids containing magnesium.
  • Review symptoms of overdose and instruct patient to report these promptly to health care professional.
  • Emphasize the importance of follow-up exams to evaluate progress.

Evaluation/Desired Outcomes

  • Normalization of serum calcium and parathyroid hormone levels.


/dox·er·cal·cif·er·ol/ (dok″ser-kal-sif´er-ol) a synthetic analogue of vitamin D, used to reduce levels of circulating parathyroid hormone in the treatment of secondary hyperparathyroidism associated with chronic renal failure.


a parathyroid agent (calcium regulator).
indications It is used to lower high parathyroid hormone levels in patients undergoing chronic kidney dialysis.
contraindications Known hypersensitivity to this drug, hyperphosphatemia, hypercalcemia, and vitamin D toxicity prohibit its use.
adverse effects Adverse effects include drowsiness, headache, lethargy, nausea, diarrhea, vomiting, anorexia, dry mouth, constipation, cramps, metallic taste, myalgia, arthralgia, decreased bone development, polyuria, hypercalciuria, hyperphosphatemia, hematuria, and shortness of breath.
References in periodicals archive ?
Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism," American Journal of Physiology: Renal Physiology, vol.
Pharmaceutical company Akorn (NasdaqGS:AKRX) stated on Monday that it has introduced Doxercalciferol Injection Solution, 4 mcg/2 ml in 2ml single-use vials in the market.
This launch follows an approval of an abbreviated new drug application for Doxercalciferol Injection Solution, 4 mcg/2 ml in 2ml single-use vials from the US Food and Drug Administration on 7 May 2015.
Pharmaceutical drug forms of activated vitamin D include calcitriol, doxercalciferol, and calcipotriene.
5% Lupin Dexmethylphenidate Hydrochloride Mylan Extended-Release Capsules, 30 mg Adefovir Dipivoxil Tablets, 10 mg Sigmapharm Adenosine Injection USP, 3 mg/ml, Teva packaged in 60 mg/20 ml and 90 mg/30 ml single-dose vials Lansoprazole Delayed-Release Capsules Teva USP, Amoxicillin Capsules USP and Clarithromycin Tablets USP, 30 mg/500 mg/500 mg Doxercalciferol Injection, 2 mcg/mi, Innopharma pack-aged in 4 mcg/2 ml single-use ampules SEPTEMBER 2013 Bivalrudin for Injection, 250 mg/vial, Hospira packaged in single-use flip-top vials Azacitidine for Injection, 100 mg, packaged Dr.
Doxercalciferol is not indicated in ESLD as sufficient hepatic mass may not be present to complete the conversion to calcitriol.
The fact that calcitriol increases levels of calcium and phosphorus, which has been associated with increased morbidity and mortality in dialysis patients, led to the development of two second-generation vitamin D sterols, paricalcitol and doxercalciferol.
Predialysis patients (and peritoneal dialysis and home hemodialysis patients) can benefit from the convenience of an oral formulation of doxercalciferol (Hectorol[R]) (Maung et al.
Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1-hyrdoxyvitamin D) in dialysis patients with secondary hyperparathyroidism: A sequential comparison.
There are currently four Vitamin D products on the market that do not require activation by the kidney: calcitriol injection (Calcijex[R], Abbott), paricalcitol injection (Zemplar[R], Abbott), oral calcitriol (Rocaltrol[R], Roche), and oral doxercalciferol (Hectorol[TM]).
One of these analogs, doxercalciferol (Hectorol), was recently approved by the Food and Drug Administration (FDA).