Only paroxetine was more acceptable than
doxepin [OR=0.11 (95%CI=0.03 to 0.85)], but paroxetine did not show a significant difference compared with a placebo.
Medications recommended for treating sleep maintenance insomnia include:
doxepin, eszopiclone, suvorexant, Zolpidem, and temazepam.
However, more recent studies have examined the use of
Doxepin for insomnia, and interest has focused on very low doses ranging from 1 to 6mg daily, as it seems to be a highly selective Histamine [H.sub.1] receptor antagonist with few related adverse events when used at very low doses.
(1) In the secretion experiments, mast cells were preincubated with different concentrations (10-8-10-4 mol/L) of selected TCAs (amitriptyline,
doxepin, imipramine, and clomipramine) for 10 min and then incubated in the presence of compound 48/80 (0.1 [micro]g/mL) for additional 10 min.
Antidepressants such as Amitriptyline or
Doxepin may help to reduce the trigger response in the larynx.
Tricyclic antidepressants such as despiramine, amitriptyline and
doxepin may also treat comorbid anxiety and depression, but adverse effects include sedation, blurred vision, constipation, dry mouth, dizziness, urinary retention and hypotension.
Antihistamines such as hydroxizine pamoate and
doxepin hydrochloride may be used in horses with urticaria [16].
"Those patients represent 70% of the market." Silenor is a low-dose formulation of the antidepressant
doxepin, which has been in use for 40 years.
A Tricyclic antidepressants (TCAs), such as amitriptyline (Amitril, Elavil), desipramine (Norpramin),
doxepin (Adapin, Sinequan), imipramine (Tofranil) and nortriptyline (Pamelor, Aventyl), are commonly used to treat chronic pain.
With respect to safety, the FDA noted that there were no adverse events observed that would preclude approval, but asked the company to address the possibility that
doxepin may prolong the cardiac QT interval.
In her early twenties, she was further diagnosed as suffering from "chemical sensitivity disorder" and was given a more serious drug,
Doxepin.
Clomipramine, fluoxetine, paroxetine, and sertraline have the highest affinity for the serotonin transporter; citalopram, fluvoxamine, and venlafaxine have intermediate affinity; and
doxepin, mirtazapine, mo-clobemide, and nortriptyline have low affinity.
