downstaging

(down'staj?ing)

Decreasing the size, extent of metastases, and/or lymph node involvement of a tumor by means of anticancer therapy.

Synonym: downsizing See: debulking

Mentioned in ?

debulking operation

References in periodicals archive ?

The Importance of Downstaging: When LT Is Feasible?

In this sense, tumor downstaging may facilitate LT for patients with HCC outside MC; however, there is no optimal protocol yet and downstaging outcomes are poorly defined [66].

Microvascular Invasion in HCC: The Molecular Imaging Perspective

The secondary outcome was the downstaging effect, which was defined as the rate of posttreatment reduction of pathological stage (including both T and/or N categories) as compared with the pretreatment clinical stage.

Adjuvant Second-Dose Chemotherapy before Surgery for Patients with Locally Advanced Rectal Malignancy Is Not Beneficial: A Systematic Review and Meta-Analysis

Radtke and colleagues first reported a markedly improved clinical outcome in patients who had pathologic downstaging by neoadjuvant chemotherapy of the urinary bladder.

Successful neoadjuvant chemotherapy for primary invasive small-cell carcinoma of the ureter

SNFs are required to report healing pressure ulcers in a sequence of "downstages," but there is no scientific rationale for downstaging. Wounds do not heal in this manner, but SNFs currently have no other option for presenting clinical documentation.

Wound Care 10-year progress report: a discussion on the ever-evolving practice of wound care

By upstaging or downstaging disease, this hybrid imaging tool may alter the management of more than one-third of patients with the disease," said Dr.

Molecular imaging may alter management of over one-third thyroid cancer patients

Of the 22 patients who underwent surgery, 14 (64%) showed a pathologic downstaging. A complete pathologic response was obtained in 9 patients (41%); 16 patients (72%) had no residual metastatic lymphadenopathy.

Trimodal approach to stage IIIB non--small cell lung cancer: Phase II trial results promising

A subsequent PET scan proved that the spots were not tumor cells, thereby downstaging the patient from clinical Stage IV to Stage I.

PET Scan After CT Often Means Recalculating Tumor Stage

From a reimbursement standpoint, the use of reverse or downstaging in long-term care stems from wound care coverage criteria - the providers' use of the resident assessment instrument (RAI) for clinical protocol.

Pressure ulcers: coping with the "reverse staging" dilemma

This multimodal treatment has the potential to induce tumor downsizing and tumor downstaging and possibly improve sphincter preservation and local control [1-3].

Effect of Neoadjuvant Chemoradiotherapy on Locally Advanced Rectal Mucinous Adenocarcinoma: A Propensity Score-Matched Study

A secondary objective was to compare the pT0 and tumour downstaging rates in patients who received radical cystectomy alone against those who received cispatin and gemcitabine (CG) neoadjuvant chemotherapy and radical cystectomy.

Referral and treatment rates of neoadjuvant chemotherapy in muscle-invasive bladder cancer before and after publication of a clinical practice guideline

In general, trials with an overall treatment time longer than 10 days have demonstrated that preoperative radiation has a downstaging effect, the investigators note.