downstaging

downstaging

(down'staj?ing)
Decreasing the size, extent of metastases, and/or lymph node involvement of a tumor by means of anticancer therapy.
Synonym: downsizing See: debulking
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Radtke and colleagues first reported a markedly improved clinical outcome in patients who had pathologic downstaging by neoadjuvant chemotherapy of the urinary bladder.
It is not clear whether neoadjuvant chemotherapy is also effective for upper urinary tract tumours, but good prognosis has been reported in patients with pathological downstaging.
The pathological downstaging and long-term survival in our case support the usefulness of neoadjuvant chemotherapy in treating primary SCC of the upper urinary tract.
Successful neoadjuvant chemotherapy for primary invasive small-cell carcinoma of the ureter
SNFs are required to report healing pressure ulcers in a sequence of "downstages," but there is no scientific rationale for downstaging.
Wound Care 10-year progress report: a discussion on the ever-evolving practice of wound care
By upstaging or downstaging disease, this hybrid imaging tool may alter the management of more than one-third of patients with the disease," said Dr.
Molecular imaging may alter management of over one-third thyroid cancer patients
Of the 22 patients who underwent surgery, 14 (64%) showed a pathologic downstaging.
Trimodal approach to stage IIIB non--small cell lung cancer: Phase II trial results promising
From a reimbursement standpoint, the use of reverse or downstaging in long-term care stems from wound care coverage criteria - the providers' use of the resident assessment instrument (RAI) for clinical protocol.
While most long-term care providers are, at this point, downstaging, there are some who are adopting a "once a stage IV, always a stage IV" stance.
If, for example, you have a surveyor who believes you should not be downstaging, yet HCFA mandates that you do so, you may end up with deficiencies that are not warranted under the guidelines.
Pressure ulcers: coping with the "reverse staging" dilemma
A secondary objective was to compare the pT0 and tumour downstaging rates in patients who received radical cystectomy alone against those who received cispatin and gemcitabine (CG) neoadjuvant chemotherapy and radical cystectomy.
Secondary outcomes were differences between patients treated with radical cystectomy alone and those treated with neoadjuvant chemotherapy plus radical cystectomy with regard to pT0 and pathologic tumour downstaging.
Referral and treatment rates of neoadjuvant chemotherapy in muscle-invasive bladder cancer before and after publication of a clinical practice guideline
In general, trials with an overall treatment time longer than 10 days have demonstrated that preoperative radiation has a downstaging effect, the investigators note.
Preop Radiation in Rectal Ca

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