downregulate


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Related to downregulate: Upregulate

downregulate

(down-rĕg′ū-lāt″)
To inhibit or suppress the normal response of an organ or system (e.g., the immune system or the central nervous system).
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It has also been reported that miR-142-3p effectively inhibits autophagy in a NOD2-dependent manner and downregulates IL-8 mRNA expression [30].
The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease
Thus, according to these data, the most beneficial miR to combine with IL-27 for reducing inflammatory activity of macrophages would be miR-21 and miR-29b (Figure 6(c), yellow arrowheads), as they downregulate or stabilize IL-17a levels and downregulate TNF and Stat3, while enhancing the effect of IL-27 on Stat1 activation.
Combination of Interleukin-27 and MicroRNA for Enhancing Expression of Anti-Inflammatory and Proosteogenic Genes
These data collectively indicate that RR downregulates UVB-induced oxidative stress more potently than NR or R alone and therefore reduces its contribution to skin aging.
Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades
The finding that heavy almost-daily cannabis use downregulates levels of FAAH after overnight cessation from cannabis use may explain the relative absence of withdrawal symptoms in very early abstinence, says Boileau, and suggests that strategies aimed at keeping levels of this enzyme down might help reduce cannabis withdrawal symptoms.
Netherlands : A FAAH Better Thing for Cannabis Users: New Insights May Aid Development of Treatments for Cannabis Use Disorder
The regulatory basis for this inability to sufficiently downregulate iron absorption is unknown, but disruptions in the hepcidin-ferroportin axis are likely candidates based on recent research in humans and laboratory rodents.
J Zoo Wildl Med.: Avian iron storage disease: variations on a common theme?
verticillata extract used in our study was found to downregulate p53.
Antiproliferative effect of hydroethanolic extracts of seeds of Cola verticillata and leaves of Solanum scabrum
And in some cases, high doses downregulate responses triggered by lesser exposures--in other words, different effects can appear and disappear at different doses.
The endocrine society issues statement of principles
To achieve their goal, a team chose to "downregulate"-- a process that involves decreasing a cellular component--the caffeic acid 3-O-methyltransferase, or COMT, gene in the Alamo variety of switchgrass.
New lignin 'lite' switchgrass boosts biofuel yield by more than one-third
MicroRNA 150 has been shown to downregulate the expression of C-MYB, a transcription factor that plays a significant role in megakaryopoiesis.
MicroRNAs in benign and malignant hematopoiesis
The kidneys perceive the pressure in the vessel and up- or downregulate the amounts of these hormones, which determines the "tone" of the vessel or the outside pressure.
Lower your blood pressure without medication
Among several approaches to prevention of Type 1 diabetes (T1D), "vaccination" using islet autoantigens (intact or altered peptides derived from insulin, [GAD.sub.65] or other proteins) stands out as potentially inducing long-term tolerance by induction of regulatory T cells that downregulate immunity to autoantigens.
When to intervene?
But the mitogen-activated protein (MAP) kinase pathway, which mediates vasoconstriction, is driven by high levels of insulin and thus, does not downregulate with insulin resistance.
Obesity, diabetes trends portend AD wave: most effective method of treating cognitive impairment might be preventing insulin resistance

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