downregulate

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Related to downregulate: Upregulate

downregulate

(down-rĕg′ū-lāt″)

To inhibit or suppress the normal response of an organ or system (e.g., the immune system or the central nervous system).

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References in periodicals archive ?

300 mg/L of rhynchophylline was added to the medium to downregulate the level of EphA4.

Exosomal MicroRNA-10a Is Associated with Liver Regeneration in Rats through Downregulation of EphA4

Mounting evidence suggests that estrogen (E2) downregulates hepcidin synthesis and increases serum iron concentration.

Estrogen-Dependent downregulation of hepcidin synthesis induces intracellular iron efflux in cancer cells in vitro

The finding that heavy almost-daily cannabis use downregulates levels of FAAH after overnight cessation from cannabis use may explain the relative absence of withdrawal symptoms in very early abstinence, says Boileau, and suggests that strategies aimed at keeping levels of this enzyme down might help reduce cannabis withdrawal symptoms.

Netherlands : A FAAH Better Thing for Cannabis Users: New Insights May Aid Development of Treatments for Cannabis Use Disorder

To determine which regions of MARCH4 are required to downregulate the surface expression of MHC I, truncated forms of MARCH4 were created.

The membrane associated RING-CH proteins: a family of E3 ligases with diverse roles through the cell

Hormones rarely display dose linearity, and in some cases, high doses downregulate responses triggered by lesser exposures--in other words, different effects can appear and disappear at different doses.

The endocrine society issues statement of principles

MicroRNA 150 has been shown to downregulate the expression of C-MYB, a transcription factor that plays a significant role in megakaryopoiesis.

MicroRNAs in benign and malignant hematopoiesis

The kidneys perceive the pressure in the vessel and up- or downregulate the amounts of these hormones, which determines the "tone" of the vessel or the outside pressure.

Lower your blood pressure without medication

65] or other proteins) stands out as potentially inducing long-term tolerance by induction of regulatory T cells that downregulate immunity to autoantigens.

When to intervene?

But the mitogen-activated protein (MAP) kinase pathway, which mediates vasoconstriction, is driven by high levels of insulin and does not downregulate with insulin resistance.

Release of these genetic stocks makes brown midrib genes known to downregulate two specific enzymes important in lignin synthesis, cinnamyl alcohol dehydrogenase (bmr-6) and O-methyltransferase (bmr-12), available in diverse near-isogenic forage sorghum backgrounds allowing direct comparison of gene effects across these broad backgrounds.

Registration of seven forage sorghum genetic stocks near-isogenic for the brown midrib genes bmr-6 and bmr-12

4) KSHV evades immune responses in part through its intrinsic ability to downregulate major histocompatibility complex (MHC)-1 surface molecules, an effect that may be decreased it T-helper depletion is prevented or restored with HAART.

The use of antiretroviral therapy in patients undergoing treatment for HIV-related neoplastic disease

Therefore, wine consumption may downregulate the immune response that leads to colds.