downregulate


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Related to downregulate: Upregulate

downregulate

(down-rĕg′ū-lāt″)
To inhibit or suppress the normal response of an organ or system (e.g., the immune system or the central nervous system).
References in periodicals archive ?
It has also been reported that miR-142-3p effectively inhibits autophagy in a NOD2-dependent manner and downregulates IL-8 mRNA expression [30].
Thus, according to these data, the most beneficial miR to combine with IL-27 for reducing inflammatory activity of macrophages would be miR-21 and miR-29b (Figure 6(c), yellow arrowheads), as they downregulate or stabilize IL-17a levels and downregulate TNF and Stat3, while enhancing the effect of IL-27 on Stat1 activation.
These data collectively indicate that RR downregulates UVB-induced oxidative stress more potently than NR or R alone and therefore reduces its contribution to skin aging.
The finding that heavy almost-daily cannabis use downregulates levels of FAAH after overnight cessation from cannabis use may explain the relative absence of withdrawal symptoms in very early abstinence, says Boileau, and suggests that strategies aimed at keeping levels of this enzyme down might help reduce cannabis withdrawal symptoms.
The regulatory basis for this inability to sufficiently downregulate iron absorption is unknown, but disruptions in the hepcidin-ferroportin axis are likely candidates based on recent research in humans and laboratory rodents.
And in some cases, high doses downregulate responses triggered by lesser exposures--in other words, different effects can appear and disappear at different doses.
To achieve their goal, a team chose to "downregulate"-- a process that involves decreasing a cellular component--the caffeic acid 3-O-methyltransferase, or COMT, gene in the Alamo variety of switchgrass.
MicroRNA 150 has been shown to downregulate the expression of C-MYB, a transcription factor that plays a significant role in megakaryopoiesis.
The kidneys perceive the pressure in the vessel and up- or downregulate the amounts of these hormones, which determines the "tone" of the vessel or the outside pressure.
Among several approaches to prevention of Type 1 diabetes (T1D), "vaccination" using islet autoantigens (intact or altered peptides derived from insulin, [GAD.sub.65] or other proteins) stands out as potentially inducing long-term tolerance by induction of regulatory T cells that downregulate immunity to autoantigens.
But the mitogen-activated protein (MAP) kinase pathway, which mediates vasoconstriction, is driven by high levels of insulin and thus, does not downregulate with insulin resistance.