downregulate


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Related to downregulate: Upregulate

downregulate

(down-rĕg′ū-lāt″)
To inhibit or suppress the normal response of an organ or system (e.g., the immune system or the central nervous system).
References in periodicals archive ?
It has also been reported that miR-142-3p effectively inhibits autophagy in a NOD2-dependent manner and downregulates IL-8 mRNA expression [30].
Thus, according to these data, the most beneficial miR to combine with IL-27 for reducing inflammatory activity of macrophages would be miR-21 and miR-29b (Figure 6(c), yellow arrowheads), as they downregulate or stabilize IL-17a levels and downregulate TNF and Stat3, while enhancing the effect of IL-27 on Stat1 activation.
These data collectively indicate that RR downregulates UVB-induced oxidative stress more potently than NR or R alone and therefore reduces its contribution to skin aging.
The regulatory basis for this inability to sufficiently downregulate iron absorption is unknown, but disruptions in the hepcidin-ferroportin axis are likely candidates based on recent research in humans and laboratory rodents.
And in some cases, high doses downregulate responses triggered by lesser exposures--in other words, different effects can appear and disappear at different doses.
To achieve their goal, a team chose to "downregulate"-- a process that involves decreasing a cellular component--the caffeic acid 3-O-methyltransferase, or COMT, gene in the Alamo variety of switchgrass.
MicroRNA 150 has been shown to downregulate the expression of C-MYB, a transcription factor that plays a significant role in megakaryopoiesis.
The kidneys perceive the pressure in the vessel and up- or downregulate the amounts of these hormones, which determines the "tone" of the vessel or the outside pressure.
Among several approaches to prevention of Type 1 diabetes (T1D), "vaccination" using islet autoantigens (intact or altered peptides derived from insulin, [GAD.sub.65] or other proteins) stands out as potentially inducing long-term tolerance by induction of regulatory T cells that downregulate immunity to autoantigens.
But the mitogen-activated protein (MAP) kinase pathway, which mediates vasoconstriction, is driven by high levels of insulin and thus, does not downregulate with insulin resistance.