down-regulation


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Related to down-regulation: Upregulation, Up-regulation

down-regulation

 [down-reg-u-la´shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent. See also up-regulation.

down-reg·u·la·tion

(down-reg'yū-lā'shŭn),
Development of a refractory or tolerant state consequent on repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent diminution in the number of receptors.

down-regulation

/down-reg·u·la·tion/ (doun reg-u-la´shun) a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent.

down-regulation

[doun reg-u-la′shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually caused by long-term exposure to the agent. See also up-regulation.
References in periodicals archive ?
Gene expression analysis of badh2 gene, gas chromatography-mass spectrometry assessment for quantitative analysis of 2AP combined with organoleptic analysis of phenotypic aroma represented that down-regulation of the recessive badh2 allele is responsible for the significant elevation of 2AP concentration and phenotypic aroma expression in the studied aromatic rice genotypes.
With more appetite neurons and fewer satiety neurons, as well as a down-regulation of reward--and an abundance of available food--a newborn is at high risk of becoming obese.
Frequent deletions and down-regulation of micro-RNAgenes miR15 and miR16at13q14 in chronic lymphocytic leukemia.
Fucoxanthin, derived from brown seaweeds, has shown anti-adipose capability through modulating the elevation of ROS, and down-regulation of lipid metabolism genes.
sup][15],[39] In addition, a recent investigation revealed that chronic miR221/222 mediated MGMT down-regulation could render glioma cells unable to repair genetic damage.
The research also revealed that down-regulation of Amdl was necessary for differentiation of ESCs into neural precursor cells and that Amdl is translationally regulated by a micro-RNA (miRNA), the first ever demonstration of miRNA-mediated regulation of the polyamine pathway.
The transgenic approach to produce high-oleic acid soybean oil is based on the down-regulation of expression (gene silencing) of two soybean fatty acid desaturase genes termed FAD2-1A and FAD2-1B.
The down-regulation of 3[beta]-HSD may occur because B[a]P can negatively target 3[beta]-HSD, which is required for testosterone production.
These cells have the potential to move the regenerative medical field beyond the classic paracrine mechanisms (neoangiogenesis and down-regulation of inflammation) toward tissue and bone repair and regeneration.
These changes were accompanied by activation of NF-kB thereby leading to enhanced levels of tumour necrosis factor-alpha, malondialdehyde and nitrite in liver and down-regulation of hepatic antioxidant defense systems.
14) In addition, a higher frequency of down-regulation of this complex has been observed for metastatic lesions than for primary lesions.