At first, we explore the effect of
doubling time on tumor expansion keeping the rest modeling parameters constant.
Overall
doubling time of 3 cell lines was reduced in the presence of CBS, while for 2 cell lives FBS proved to be better growth stimulant.
If
doubling time is known, how can it help defense counsel construct a defense that shows that any alleged delay in diagnosis had no relation to a poor outcome?
Widespread recommendations from the family practice and obstetrics literature encourage the use of a simple 48-hour
doubling time standard without emphasis on its limitations.[8,13,14] Thus, in case 1, the radiologist's original ultrasonogram interpretation of "most consistent with a blighted ovum," (confirmed 1 week later by a "no change" reading) was "substantiated" by the failure of [beta]-HCG levels to double appropriately.
(1) Again, PSA
doubling time increased, from 15 months at baseline to 60 months at follow-up.
PSA kinetics are important, for helping us identify patients at risk of early death, but there is no standard technique to determine PSA
doubling time. Failure at less than 3 years, Gleasonscore of 8 or more, and a short
doubling time (less than 3 months) are all important signs of heightened risk.
We identify an inverse relationship between the average CFR and the average
doubling time for different countries (Figure 2).
PSA kinetics are important for helping us identify patients at risk of early death, but there is no standard technique to determine PSA
doubling time. Failure at less than 3 years, Gleason score of 8 or more, and a short
doubling time (less than 3 months) are all important signs of heightened risk.
A total of 10 of the 19 high-risk patients and all of the low-risk patients (9) who were treated with radioimmunotherapy had favorable biologic responses, defined as increase in calcitonin
doubling time of more than 100% after treatment, compared with pretreatment.
Those men whose testing during the surveillance period revealed a PSA
doubling time of 3 years or less and/or grade progression on rebiopsy to a Gleason score of 7 or higher, as well as those who chose not to continue on active surveillance, were offered radical intervention.
Men whose testing during the surveillance period showed a PSA
doubling time of 3 years or less and/or grade progression on re-biopsy to a Gleason score of 7 or higher, as well as those who chose not to continue on active surveillance, were offered radical intervention.
The median PSA
doubling time in the cohort was 7 years.
