double-blind trial

double-blind trial

A test of the real effect of a new medical treatment, in which neither the patient nor the persons conducting the trial know which of two identical-seeming treatments is genuine and which is not. Trials not conducted in this way cannot be relied on to provide reliable evidence of the efficacy of a treatment because of the power of the placebo effect and of psychological suggestion.
References in periodicals archive ?
Approval is based on results from a randomized, double-blind trial of 1,019 patients with completely resected stage III melanoma, who received either placebo or 200 mg of pembrolizumab every 3 weeks for up to 1 year until disease recurrence or unacceptable toxicity.
The Phase 3 global, randomised, double-blind trial is evaluating CYRAMZA in combination with erlotinib, compared to placebo in combination with erlotinib, as a first-line treatment in patients with metastatic non-small cell lung cancer (NSCLC) whose tumours have activating EGFR mutations.
The Phase 3 global, randomized, double-blind trial is evaluating Cyramza in combination with erlotinib, compared to placebo in combination with erlotinib, as a first-line treatment in patients with metastatic non-small cell lung cancer, or NSCLC, whose tumors have activating EGFR mutations.
A double-blind trial revealed the positive effect of curcumin on memory and mood in people with mild, age-related cognitive decline.*
Ninety-three patients not in remission continued to the six-week double-blind trial; 77 percent completed the trial.
Worldwide will support Aurinia's randomized, placebo-controlled, double-blind trial in approximately 320 patients.
In a double-blind trial, testers saw improvements in skin moisture, elasticity AND wrinkles after eating a daily 7g bar for three weeks.
The PROTECT 2 study was a global, randomized, double-blind trial involving 308 patients carried out in the United States, Latin America, Asia and Europe.
SAN FRANCISCO--Patients with symptomatic knee osteoarthritis who received pharmaceutical-grade chondroitin sulfate for 2 years lost about 20% less cartilage volume than did patients treated with celecoxib, according to a randomized, double-blind trial. Improvements were limited to the medial tibiofemoral compartment, but even modest structural effects can cut the need for total knee replacement, said Dr.
The REMIT (Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment) study, a randomized, double-blind trial of patients with stable coronary heart disease and mental stress-induced myocardial ischemia (MSIMI, decreased blood flow to the heart) was designed to examine the effect of the antidepressant escitalopram (Lexapro) on heart health.
The researchers compared ingenol mebutate gel to a placebo gel in a randomized, double-blind trial of 1,005 patients treated at four medical centers.
In the current study, 45 patients with moderate to advanced Parkinson's disease who were not adequately controlled with current therapies were enrolled in the double-blind trial, with half randomized to receive the gene therapy and the other half to a "sham surgery"-a mock procedure designed to make patients think they could have received the experimental approach.