The majority of these studies used alprazolam as the benzodiazepine (other benzodiazepines used were adinazolam, bromazepam, chlordiazepoxide, and lorazepam) and imipramine or amitriptyline as the antidepressant comparator (other antidepressants used were desipramine, dothiepin
, doxepin, and only one newer antidepressant, fluvoxamine, in one study).
Cases have been described where amitriptyline and dothiepin
(the analogue of amitriptyline used in Europe) have been used to get a feeling of euphoria.
Basavaiah, "Spectrophotometric determination of dothiepin
hydrochloride in pharmaceuticals through ion-pair complexation reaction," Chemical Industry and Chemical Engineering Quarterly, vol.
Annual spend - PS9,002,824 | Dosulepin - formerly known as dothiepin
, it is a tricyclic antidepressant.
The antidepressant drugs successfully reversed by Intralipid include: dothiepin
, amitriptyline, fluoxetine, sertraline, dosulepin, venlafaxine, and bupropion.
Ferraro, "Hyponatraemia and confusion in a 70-year-old female when bupropion was added to dothiepin
and escitalopram," Australasian Psychiatry, vol.
The findings of the present study revealed that SSRIs formed about half of the prescriptions of all antidepressants, serotonin-norepinephrine reuptake inhibitors formed 11.6% (55 out of 476) of all antidepressant prescriptions, and older antidepressants (trazodone, imipramine, clomipramine, amitriptyline, mianserin, doxepin and dothiepin
) formed 19.1% (91 out of 476).
A comparative study of acute and subchronic effects of dothiepin
, fluoxetine and placebo on psychomotor and actual driving performance.
The antidepressants used by these students were citalopram, fluoxetine and dothiepin
Greater toxicity in overdose of dothiepin
than of other tricyclic antidepressants.
Generic TCAs detection on the biochip array test site (100ng/ml cut-off) TCA %cross-reactivity Nortriptyline 100 Imipramine N-oxide 1335.7 Opipramol 386.0 Trimipramine 375.0 Imipramine 217.4 Cyclobenzaprine 170.6 Desipramine 131.2 Amitriptyline 71.8 Doxepin 71.4 Protriptyline 49.9 Promazine 48.7 Dothiepin
39.4 Maprotiline 28.3 Cyproheptadine 20.2
Toxicology results from a postmortem showed the presence of alcohol and an anti-depressant drug Dothiepin