dosing interval

dosing interval

Therapeutics The frequency of intermittent drug administration, based on the drug's half-life. See Slow-release drug.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In Phase 2 studies, inclisiran provided clinically significant LDL-C reductions greater than 50 % in addition to the effects of statins and/or ezetimibe, and LDL-C reductions were sustained throughout the six-month dosing interval.
"We believe ULTOMIRIS will become the new standard of care for patients with PNH by providing immediate and complete C5 inhibition, sustained throughout the eight week dosing interval, and reducing the number of infusions per year from 26 with SOLIRIS to only six or seven with ULTOMIRIS.
The pharmacokinetic profile of vecabrutinib showed sustained exposure over the dosing interval, with median steady-state trough concentrations increasing with dose.
The dosing interval can be shortened to a minimum of 1 week depending on patients' disease symptoms.
B's hallucinations only appeared at the end of the dosing interval, it is reasonable to expect that his new regimen would be successful in suppressing his hallucinations.
Even though the dosing interval of eculizumab initially was 300 mg every second week as recommended by the producer, we increased the interval to 3 weeks without dose alteration; we could demonstrate complete inhibition of the complement activity for more than 6 years paralleled by normal growth development and no signs of renal failure.
In this trial, higher antibody responses were found for the 12-month dosing interval than for the 6-month interval, although both regimens produced an adequate response.
Maintenance doses require adjustment via dose reduction, lengthening the dosing interval, or both (Khanal, Castelino, Peterson, & Jose, 2013).
Alprolix may be administered prophylactically with an initial dose every seven days or 10 days with the ability to adjust the dosing interval based on individual response.
It may also indicate a need to dose animals twice daily, a dosing interval that may prove inconvenient for some bird owners.