dosing interval

dosing interval

Therapeutics The frequency of intermittent drug administration, based on the drug's half-life. See Slow-release drug.
References in periodicals archive ?
SGN-CD48A will be administered at an initial dosing interval of every three weeks.
The new data recommends extending the dosing interval during the first year of treatment.
s (NASDAQ: REGN) supplemental biologics license application (sBLA) for a 12-week dosing interval of Eylea (aflibercept) Injection in patients with wet age-related macular degeneration (wet AMD) based on physician's assessment, the company said.
3) Some of these formulations may be preferred for tolerability advantages vs extending the dosing interval (eg, regular-release and extended-release lithium tablets have the same half-life of approximately 18 to 36 hours; however, the extended-release formulation has a longer time to peak serum concentration, approximately 2 to 6 hours vs 0.
In this trial, higher antibody responses were found for the 12-month dosing interval than for the 6-month interval, although both regimens produced an adequate response.
Maintenance doses require adjustment via dose reduction, lengthening the dosing interval, or both (Khanal, Castelino, Peterson, & Jose, 2013).
Alprolix may be administered prophylactically with an initial dose every seven days or 10 days with the ability to adjust the dosing interval based on individual response.
It may also indicate a need to dose animals twice daily, a dosing interval that may prove inconvenient for some bird owners.
T > MIC of cephalosporin needs to reach the dosing interval of 40-60% in order to get a good clinical efficacy.
Antibiotic therapy in infants with invasive GBS disease Clinical presentation Penicillin G Ampicillin Duration of (units/kg per (mg/ kg antibiotics day) * per day) (days) Bacteraemia without 75 000-150 000 100-200 10-14 a focus Sepsis 75 000-150 000 100-200 10-14 Pneumonia 75 000-150 000 100-200 10-14 Urinary tract 75 000-150 000 100-200 10-14 infection Cellulitis 75 000-150 000 100-200 10-14 Septic arthritis 75 000-150 000 100-200 14-21 Osteomyelitis 75 000-150 000 100-200 21-28 Meningitis 450 000-500 000 200-300 21 * The recommended dosing interval for Penicillin G is 8 or 12 hourly, except for meningitis, for which the recommendation is 6 hourly.
Due to the high price of the drug, the majority of researchers were looking for the lowest dose and longest dosing interval of omalizumab that were effective in inducing symptom control in the majority of patients.