dose-response curve

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curve

 [kerv]
a line that is not straight, or that describes part of a circle, especially a line representing varying values in a graph.
dose-effect curve (dose-response curve) a graphic representation of the effect caused by an agent (such as a drug or radiation) plotted against the dose, showing the relationship of the effect to changes in the dose.
growth curve the curve obtained by plotting increase in size or numbers against the elapsed time.
oxyhemoglobin dissociation curve a graphic curve representing the normal variation in the amount of oxygen that combines with hemoglobin as a function of the partial pressures of oxygen and carbon dioxide. The curve is said to shift to the right when less than a normal amount of oxygen is taken up by the blood at a given Po2, and to shift to the left when more than a normal amount is taken up. Factors influencing the shape of the curve include changes in the blood pH, Pco2, and temperature; the presence of carbon monoxide; alterations in the constituents of the erythrocytes; and certain disease states.
pulse curve sphygmogram.
Spee curve (curve of Spee) the anatomic curvature of the occlusal alignment of teeth, beginning at the tip of the lower canine, following the buccal cusps of the premolars and molars, and continuing to the anterior border of the ramus.
strength-duration curve a graphic representation of the relationship between the intensity of an electric stimulus at the motor point of a muscle and the length of time it must flow to elicit a minimal contraction; see also chronaxie and rheobase. In cardiac pacing it is useful in determining characteristics of a particular pacing electrode and determining the most efficient selection of pacing parameters for an appropriate safety margin.
survival curve a graph of the probability of survival versus time, commonly used to present the results of clinical trials, e.g., a graph of the fraction of patients surviving (until death, relapse, or some other defined endpoint) at each time after a certain therapeutic procedure.

dose-·re·sponse curve

a graph showing the relationship between (for example, dosage of a drug, infectious agent) and the biologic response.

dose-response curve

A graphic representation of the effects that varous doses of an agent–eg, ionizing radiation or a chemotherapeutic agent, have on a given parameter–eg, cell viability, mutation frequency, DNA damage, tumor growth or metastasis or other behavior Therapeutics A graphic representation of the effectiveness or toxicity of a drug vs the dose administered
References in periodicals archive ?
Moreover, we compared NtCs with the NOEC values for a sub-set of the dose-response data and with the modeled NECs for all dose-response curves. The algorithm is available as scripts in different programming languages, as well as in a free, user-friendly online application.
The dose-response curves generated by this approach made it possible to accurately calculate key parameters such as the MBEC50 (the minimum biofilm eradicating concentration that removes 50% of the biofilm) for each treatment.
Vandenberg (2014) reported that non-monotonic dose-response curves are common with BPA and around 24% of in-vitro experiments with BPA showed non-monotonic response.
Candidate chemicals were selected for inclusion in our multi-component mixtures if they met the following criteria: a) They had to be able to suppress testosterone synthesis in the FEGA, and b) they had to show dose-response curves with almost complete inhibition of testosterone synthesis.
Using varying concentrations (10-9-10-6M) the cumulative dose-response curves of acetylcholine was constructed.
When the dose-response curves were performed after acute acidosis, the blood pressure increase by Phe was the same for the control and AMA groups (Figure 8A and B).
Methods: [L.sub.[phi]] and confidence intervals were determined in vitro with the MixLow method, once the estimated parameters from the dose-response curves of independent extracts and mixtures, were obtained.
Dose-response curves, safe intravenous (IV) dose, therapeutic index (TI), therapeutic ratio (TR) and safety factor (SF):
Assay specificity tests by constructing dose-response curves for synthetic hepcidin-20, -22, -24, and -25 showed that the Anticalin-based assay detected hepcidin-25, as well as all 3 smaller isoforms, virtually indistinguishably.
From the dose-response curves of DA/NA, a submaximal dose of each agonist was selected for further studies.
Finally, the EFSA recommends clarifying, in a wider context, the issues of thresholds and toxicity criteria (what constitutes a toxic effect on health as opposed to an adaptive response) as well as the issue of exposure to multiple chemcial substances and non-monotonic dose-response curves. Furthermore, the opinion notes that there is a lack of international consensus on the existence/relevance of low dose effects' (responses to much lower doses than the lowest dose of 1 mg/kg of body weight used in toxicology tests).