dose-response curve

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a line that is not straight, or that describes part of a circle, especially a line representing varying values in a graph.
dose-effect curve (dose-response curve) a graphic representation of the effect caused by an agent (such as a drug or radiation) plotted against the dose, showing the relationship of the effect to changes in the dose.
growth curve the curve obtained by plotting increase in size or numbers against the elapsed time.
oxyhemoglobin dissociation curve a graphic curve representing the normal variation in the amount of oxygen that combines with hemoglobin as a function of the partial pressures of oxygen and carbon dioxide. The curve is said to shift to the right when less than a normal amount of oxygen is taken up by the blood at a given Po2, and to shift to the left when more than a normal amount is taken up. Factors influencing the shape of the curve include changes in the blood pH, Pco2, and temperature; the presence of carbon monoxide; alterations in the constituents of the erythrocytes; and certain disease states.
pulse curve sphygmogram.
Spee curve (curve of Spee) the anatomic curvature of the occlusal alignment of teeth, beginning at the tip of the lower canine, following the buccal cusps of the premolars and molars, and continuing to the anterior border of the ramus.
strength-duration curve a graphic representation of the relationship between the intensity of an electric stimulus at the motor point of a muscle and the length of time it must flow to elicit a minimal contraction; see also chronaxie and rheobase. In cardiac pacing it is useful in determining characteristics of a particular pacing electrode and determining the most efficient selection of pacing parameters for an appropriate safety margin.
survival curve a graph of the probability of survival versus time, commonly used to present the results of clinical trials, e.g., a graph of the fraction of patients surviving (until death, relapse, or some other defined endpoint) at each time after a certain therapeutic procedure.

dose-·re·sponse curve

a graph showing the relationship between (for example, dosage of a drug, infectious agent) and the biologic response.

dose-response curve

A graphic representation of the effects that varous doses of an agent–eg, ionizing radiation or a chemotherapeutic agent, have on a given parameter–eg, cell viability, mutation frequency, DNA damage, tumor growth or metastasis or other behavior Therapeutics A graphic representation of the effectiveness or toxicity of a drug vs the dose administered
References in periodicals archive ?
phi]] and confidence intervals were determined in vitro with the MixLow method, once the estimated parameters from the dose-response curves of independent extracts and mixtures, were obtained.
Without solid scientific backing for the shape of dose-response curves, particularly in the low-dose region, government agencies use linear non-threshold extrapol ation models as default risk assessment tools [National Research Council (NRC) 2009].
Dose-response curves, safe intravenous (IV) dose, therapeutic index (TI), therapeutic ratio (TR) and safety factor (SF):
Assay specificity tests by constructing dose-response curves for synthetic hepcidin-20, -22, -24, and -25 showed that the Anticalin-based assay detected hepcidin-25, as well as all 3 smaller isoforms, virtually indistinguishably.
From 12 studies reporting separate data on wine or beer consumption, two closely overlapping dose-response curves were obtained suggesting maximal protection of 33 percent at 25 g/day of alcohol approximately (2 drinks/day by US standards and 3 units for the UK) for vascular diseases.
When researchers seek to establish the optimal dose of an intervention, whether it be a dietary supplement or other lifestyle choice such as exercise, we generate what are called dose-response curves.
The dose response curves for optimum insertion conditions for the present and our other two previous studies (6,7) were compared for parallelism by comparing the straight lines of best fit to the sigma shaped dose-response curves using the t-test method outlined by Tallarida (13), incorporated into PharmTools Pro software, (McCary Group, Elkins Park, PA, USA).
Dose-response curves of the 54 primary colorectal cultures revealed that eight (8) percent of the cultures tested were responsive to cetuximab, 22 percent had an intermediate response, and 70 percent were deemed non-responsive.
An additional study has confirmed the nonlinearity of dose-response curves at high and low signal intensities over a range of instrument gain settings (6).
17) when expressing their transformation frequency data as relative risk (RR), found the dose-response curves for neoplastic transformation were similar to and overlapped those for breast cancer and leukemia induction in humans, supporting the occurrence of radiation ANP against human cancers.
Dose-response curves were determined for d-amphetamine, for dopaminergic antagonists SCH23390, eticlopride, and flupenthixol, and for dopaminergic agonists SKF38393 and quinpirole.
Focusing on mammalian cases, they begin with a discussion of toxicity at the cellular level, examining biomolecular targets of toxic agents, the science of oncogenes and tumor suppressors, elementary mathematical analysis of cell survival and the shape of dose-response curves, the biological implications of the "target theory" model of cellular life and death.