dose-response curve


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curve

 [kerv]
a line that is not straight, or that describes part of a circle, especially a line representing varying values in a graph.
dose-effect curve (dose-response curve) a graphic representation of the effect caused by an agent (such as a drug or radiation) plotted against the dose, showing the relationship of the effect to changes in the dose.
growth curve the curve obtained by plotting increase in size or numbers against the elapsed time.
oxyhemoglobin dissociation curve a graphic curve representing the normal variation in the amount of oxygen that combines with hemoglobin as a function of the partial pressures of oxygen and carbon dioxide. The curve is said to shift to the right when less than a normal amount of oxygen is taken up by the blood at a given Po2, and to shift to the left when more than a normal amount is taken up. Factors influencing the shape of the curve include changes in the blood pH, Pco2, and temperature; the presence of carbon monoxide; alterations in the constituents of the erythrocytes; and certain disease states.
pulse curve sphygmogram.
Spee curve (curve of Spee) the anatomic curvature of the occlusal alignment of teeth, beginning at the tip of the lower canine, following the buccal cusps of the premolars and molars, and continuing to the anterior border of the ramus.
strength-duration curve a graphic representation of the relationship between the intensity of an electric stimulus at the motor point of a muscle and the length of time it must flow to elicit a minimal contraction; see also chronaxie and rheobase. In cardiac pacing it is useful in determining characteristics of a particular pacing electrode and determining the most efficient selection of pacing parameters for an appropriate safety margin.
survival curve a graph of the probability of survival versus time, commonly used to present the results of clinical trials, e.g., a graph of the fraction of patients surviving (until death, relapse, or some other defined endpoint) at each time after a certain therapeutic procedure.

dose-·re·sponse curve

a graph showing the relationship between (for example, dosage of a drug, infectious agent) and the biologic response.

dose-response curve

A graphic representation of the effects that varous doses of an agent–eg, ionizing radiation or a chemotherapeutic agent, have on a given parameter–eg, cell viability, mutation frequency, DNA damage, tumor growth or metastasis or other behavior Therapeutics A graphic representation of the effectiveness or toxicity of a drug vs the dose administered
References in periodicals archive ?
CaL] suppression in generating the decline phase of the inverted U-shaped dose-response curve, we observed that mimicking BPA's suppression of [I.
This end point should then determine the dose-response curve and hormetic phenomena therein.
As expected, the uterus demonstrated a monotonic dose-response curve to [E.
Employing such approaches can cause one to conclude that an LNT-type dose-response curve is real when actually there is a reduced risk at low doses and dose rates and/or a threshold dose for excess risk.
Fixed-dose ratio combinations were prepared, as described above, and assayed for construct the dose-response curve for the combination and calculate the corresponding experimental [ED.
With respect to the alcohol-CDT dose-response curve, smoking had a substantial effect on the CDT response to alcohol intake.
In a separate poster presentation, Panacos reported additional data from Study 203, confirming the top of the dose-response curve was achieved at doses of less than 400mg daily in a liquid formulation.
The choice of a specific UF to take into account the fact that the PoD is not risk free will be influenced by shape of the dose-response curve below the PoD.
A dose-response curve was observed, with the majority of responses occurring in patients treated at the higher dose levels.
That's an unusual dose-response curve," he said, and a later study was unable to reproduce the same favorable results (Ann.