dose response curve


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dose response curve

A graph charting the effect of a specific dose of drug, chemical, or ionizing radiation.
See also: curve
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References in periodicals archive ?
Three groups were made as under: Group 1: Dose response curve was made using cumulatively increasing concentrations of ranitidine (1.4-70 ug) on isolated piece of duodenum (n=6) of rabbits20.
Figure 1 shows a comparison of the dose response curves giving the TCP calculated with these different methods as a function of the total dose delivered in 2 Gy per fraction for a rapidly proliferating tumor ([T.sub.D] = 2 days) and a slowly proliferating tumor ([T.sub.D] = 14 days) with the same intrinsic sensitivity (S[F.sub.2] = 0.5).
Because the majority of Daubert courts have rejected attempted use of a monotonic, linear non-threshold dose-response curve, a Daubert court should find that the EDC low dose theory and the corresponding use of a nonmonotonic, non-threshold dose response curve are at best only a working hypothesis.
In light of this information and the lack of a dose response curve for QTc interval prolongation, ziprasidone is even beginning to be utilized at doses between 160 and 320 mg/day, particularly in difficult cases.
Each point on the dose response curve exemplifies the mean optical density measurement of three films which have an identical dose.
In group I, cumulative dose response curve of insulin was constructed using the concentrations ranging from of 10-7 to 10-3 M.
The finding of improvement over placebo at the low dose of ataluren but not at the high dose is consistent with subsequent analysis of non-clinical data which suggest a bell-shaped dose response curve as a class-based effect for drugs that promote nonsense suppression.
Samples were tested by in vitro antitrypanosomal assay system by a dose response curve using Alamar Blue sensitivity assay according to the method reported by Raz et al.
The use of sigmoidal dose response curves in soil ecotoxicological research.
From the [ED.sub.50] calculated from the dose response curves (Figures 3(a) and 3(b)), MAE was found to be approximately 3.8x less potent ([ED.sub.50]=12.26[+ or -]3.90) than diclofenac ([ED.sub.50]=3.22[+ or -]4.45) in reducing neutrophil infiltration and 3.5x less potent ([ED.sub.50]=60.57[+ or -]15.82) than diclofenac ([ED.sub.50]=17.13[+ or -]17.11) in reducing exudate formation.