dose response


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Related to dose response: Dose Response Curve

dose response

a range of doses over which response occurs. Doses lower than the threshold produce no response while those in excess of the threshold exert no additional response. The shape of the curve is usually hyperbolic when plotted with linear axes and gives a sigmoidal curve when response is plotted versus the log of the dose. Beneficial drug responses are typically plotted on separate dose response curves. Because the dose response and the chemotherapeutic index can overlap to some degree and may have different slopes, the margin of safety is often considered to be a better index.

dose response

1. The relationship between the quantity or intensity of a treatment regimen and its effect on living cells, tissues, or organisms.
2. The relationship between the intensity of an exposure, e.g., to an infectious pathogen, physical stressor, or a toxin, and its effect on living organisms.
See also: response

dose

the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.

absorbed dose
that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in Grays.
air dose
the intensity of an x- or gamma-ray beam in air, expressed in coulombs per kilogram.
booster dose
an amount of immunogen (vaccine, toxoid or other antigen preparation), sometimes smaller than the original amount, injected at an appropriate interval after primary immunization to enhance and sustain the immune response to that immunogen.
curative dose (CD)
a dose that is sufficient to restore normal health.
divided dose
a fraction of the total quantity of a drug prescribed to be given at intervals, usually during a 24-hour period.
dose equivalent limits
the limits of ionizing radiation set for radiation workers and the general public by the International Commission on Radiological Protection. For radiology workers this limit for the whole body is 50 mSv.
fatal dose
lethal dose.
dose fractions
in radiation therapy, the small doses given to reach the total radiation dose during the treatment period.
infectious dose 50 (ID50)
that amount of pathogenic microorganisms that will produce infection in 50% of the test subjects.
infective dose (ID)
that amount of pathogenic microorganisms that will cause infection in susceptible subjects.
lethal dose (LD)
the amount of toxin or drug that will kill an animal.
dose level
the amount administered per unit of body weight.
loading dose
the initial large dose of a drug given to bring tissue and fluid levels to an effective concentration quickly. Called also priming dose.
maintenance dose
the smaller doses given to maintain effective levels in body fluids and tissues after the loading dose has achieved the concentration desired.
maximum permissible dose
see dose equivalent limits (above).
median curative dose (CD50)
a dose that abolishes signs in 50% of test animals.
median effective dose (MED)
the dose that produces the desired effect in 50% of the test animals.
median lethal dose (MD50)
the quantity of an agent that will kill 50% of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50% of individuals in a large group or population.
minimum lethal dose (MLD)
the lowest dose which kills all of the test subjects.
dose rate
the amount administered per unit of time.
dose response
1. the incremental change in the subject per unit of additional dose. The response as a function of the dose.
2. the frequency of occurrence of a disease as the intake of the suspected risk factor increases. The relationship is expressed by the proximity of the illustrative curve to the expected relationship.
skin dose
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
tolerance dose
the largest quantity of an agent that may be administered without harm.
References in periodicals archive ?
Group-3: Dose response curve was constructed using fixed dose of ranitidine (28 ug) plus cumulatively increasing concentrations of metoclopramide (6-30 ug) on isolated piece of duodenum (n=6) of rabbits21.
Such considerations have led to the suggestion that thresholds can only be defined for individuals (or individual cells) and that population heterogeneity will tend to linearize the averaged dose response and obscure the threshold (Lutz 1990, 2001; White et al.
Previously we hypothesized that the opposing actions of estrogen receptor (ER) [alpha] and ER[beta] contribute to the nonmonotonic dose response of BPA in the heart (Belcher et al.
Consequently, the dose response for humans is possibly quite different from that for inbred animal strains.
Briefly, we (Calabrese and Baldwin 2001) estimated the frequency of hormesis using a priori entry and evaluative criteria; some 668 dose responses satisfied the entry criteria.
KEY WORDS: adaptive response, biphasic, dose response, hormesis, hormetic, linear dose response, risk assessment, threshold dose response, U-shaped.
Results from the previously disclosed phase 2 dose ranging study indicated a clear dose response for Aquavan Injection and a promising therapeutic profile.
2] to Figure 1C and 1D; the order of magnitude difference of the dose response between fine and ultrafine particles is obvious, regardless of whether the ultrafines are considered to be 20 or 30 nm in size.
Across the low, mid, and high Bio-E-Gel doses tested in the Phase III trial, there was a clear dose response in the reduction in the number and severity of hot flashes.
KEY WORDS: bidirectional dose response, biphasic dose response, hormesis, nonmonotonic dose response.
Across the low, mid, and high doses tested in the Phase III trial, it was reported that there was a clear dose response in the reduction in the number and severity of hot flashes.
Labeling a dose response as hormetic to justify higher exposures and claimed benefits for the general population without providing scientific evidence is counter to public-health protective assumptions.