dose escalation

dose escalation

A progressive increase in the strength of any treatment (e.g., a drug or a radiation dose), to improve its tolerability or maximize its effect.
References in periodicals archive ?
The trial is comprised of a dose escalation stage and a dose expansion stage.
No treatment-related serious adverse events have been observed to-date in any cohorts and dose escalation is continuing.
This trial includes a dose escalation strategy in the first group of patients, using a 3+3 design.
We look forward to continuing the dose escalation, as we believe that the target dose level is likely to be between 100 mg and 300 mg BID.
It allows dose distribution to the target area and controls the dose escalation. But, dose escalation of a dose is also associated with toxicities.
"A strategy of allopurinol dose escalation, which in current real-life practice is characterized by limited dose increases, is unlikely to improve the survival of patients with gout," the authors write.
In the treatment of gout, dose escalation of allopurinol to achieve target serum urate levels at or below 6 mg/ dL appears safe and effective, even among patients with chronic kidney disease, according to a new open-label, extension study.
Gradual dose escalation of allopurinol achieved target serum urate levels without causing excess adverse effects in patients with gout who tolerated but responded inadequately to creatinine clearance-based dosing, including in patients with chronic kidney disease, investigators reported in Annals of the Rheumatic Diseases.
I will argue that brachytherapy is not "the best" but only one method of biological dose escalation. The Oxford Dictionary defines "best" as "of the most excellent or desirable type or quality." External beam radiation, particularly when delivered in an accurate and precise way, gives equally excellent outcomes, can be given safely to more men and at a lower cost.
The lithium salt of GLA (LiGLA) can be administered intravenously and a dose escalation study of a 10 day infusion followed by oral therapy in patients with inoperable pancreatic cancer was carried out in 48 patients in two centres.
The initial dose escalation phase of the trial will enroll cohorts of up to 6 patients per dose.
A maximum of three cohorts will be enrolled in the REOLYSIN(R) dose escalation portion.