dose dependence

dose dependence

Concentration dependence Therapeutics The change in certain pharmacokinetic parameters–clearance, half-life, bioavailable fraction–as a function of administered dose
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Pharmacokinetics of amoxicillin: dose dependence after intravenous, oral, and intramuscular administration.
All AEs reported as related to SB-913 were mild, resolved without treatment, and did not show evidence of dose dependence. Two SAEs were reported and both were determined by the site investigator to be due to primary MPS II disease and unrelated to SB-913 treatment.
(5) Linear dose dependence of Cmax and area under the curve (AUC) was observed for the active metabolites following single or multiple doses of deutetrabenazine (6 to 24 mg and 7.5 to 22.5 mg, twice daily).
The dose dependence of the stimuli that elicited significant EAG responses was also tested.
Peak response to dosing occurs between 10 and 14 days after dose administration and also appears to have some dose dependence [24].
ED treatment includes erection-supporting vacuum pumps, psychological sex therapy, intra-urethral or intracavernosal injections of vasoactive substances (the prostaglandin analogue alprostadil), and oral dopamine receptor agonists (apomorphine); the most effective therapies are PDE-5 inhibitors.[sup.13] All three PDE-5 inhibitors available on the market (sildenafil, vardenafil, and tadalafil) display good efficacy, with sildenafil having the best efficacy (84%).[sup.12] These inhibitors are thought to produce adverse secondary effects with similar frequency, severity, and dose dependence, but further studies are required to confirm the incidence of adverse events, especially in relation to the lesser prescribed vardenafil and tadalafil.[sup.12]
Research shows that various components of the placebo effect -- for example, the paraphernalia of care (pills and syringes) and the patient-provider relationship -- can be added incrementally in a manner analogous to dose dependence (the higher the dose, the greater the effect).
The NPL/Harwell data display significant dose dependence for the TC values and TC curve shapes.
He speculated that it may be an issue of dose dependence, based on data from the phase II RE-DEEM study of dabigatran in patients with acute coronary syndrome.
Strongly superlinear dose dependence of thermoluminescence in synthetic quartz.
This objective required fulfillment of numerous criteria: low background with no interference from endogenous hormone, robust and statistically significant responses, dose dependence, and low threshold.