dose dependence

Concentration dependence Therapeutics The change in certain pharmacokinetic parameters–clearance, half-life, bioavailable fraction–as a function of administered dose

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Pharmacokinetics of amoxicillin: dose dependence after intravenous, oral, and intramuscular administration.

DOSE OPTIMIZATION AND PHARMACOKINETIC/PHARMACODYNAMIC INTEGRATION OF AMOXICILLIN IN LOHI SHEEP (Ovis aries) AND BEETAL GOATS (Capra hircus)

All AEs reported as related to SB-913 were mild, resolved without treatment, and did not show evidence of dose dependence. Two SAEs were reported and both were determined by the site investigator to be due to primary MPS II disease and unrelated to SB-913 treatment.

Sangamo reports 16 week reductions in urinary glycosaminoglycans in SB-913 study

(5) Linear dose dependence of Cmax and area under the curve (AUC) was observed for the active metabolites following single or multiple doses of deutetrabenazine (6 to 24 mg and 7.5 to 22.5 mg, twice daily).

Deutetrabenazine for tardive dyskinesia

The dose dependence of the stimuli that elicited significant EAG responses was also tested.

Screening of essential oil antifeedants in the elm pest Ambrostoma quadriimpressum (Coleoptera: Chrysomelidae)

Peak response to dosing occurs between 10 and 14 days after dose administration and also appears to have some dose dependence [24].

Balancing Therapy with Thrombopoietin Receptor Agonists and Splenectomy in Refractory Immune Thrombocytopenic Purpura: A Case of Postsplenectomy Thrombocytosis Requiring Plateletpheresis

ED treatment includes erection-supporting vacuum pumps, psychological sex therapy, intra-urethral or intracavernosal injections of vasoactive substances (the prostaglandin analogue alprostadil), and oral dopamine receptor agonists (apomorphine); the most effective therapies are PDE-5 inhibitors.[sup.13] All three PDE-5 inhibitors available on the market (sildenafil, vardenafil, and tadalafil) display good efficacy, with sildenafil having the best efficacy (84%).[sup.12] These inhibitors are thought to produce adverse secondary effects with similar frequency, severity, and dose dependence, but further studies are required to confirm the incidence of adverse events, especially in relation to the lesser prescribed vardenafil and tadalafil.[sup.12]

Sildenafil can induce the onset of a cluster headache bout

Research shows that various components of the placebo effect -- for example, the paraphernalia of care (pills and syringes) and the patient-provider relationship -- can be added incrementally in a manner analogous to dose dependence (the higher the dose, the greater the effect).

Inside the Placebo Effect

The NPL/Harwell data display significant dose dependence for the TC values and TC curve shapes.

A comparison of Harwell & FWT alanine temperature coefficients from 25 [degrees]C to 80 [degrees]C

Although no specific conclusion was reported, the researchers did not find evidence of dose dependence.

PPI therapy: when to worry about fracture risk: high-dose, long-term use of proton pump inhibitors may increase fracture risk, but the evidence is inconclusive. Here's what to keep in mind

He speculated that it may be an issue of dose dependence, based on data from the phase II RE-DEEM study of dabigatran in patients with acute coronary syndrome.

Dabigatran curbs bleeding in VTE prophylaxis

Strongly superlinear dose dependence of thermoluminescence in synthetic quartz.

Variation on luminescence effect of natural quarts extracted form vellar river seidements

This objective required fulfillment of numerous criteria: low background with no interference from endogenous hormone, robust and statistically significant responses, dose dependence, and low threshold.

A rapid, physiologic protocol for testing transcriptional effects of thyroid-disrupting agents in premetamorphic xenopus tadpoles

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