dosage compensation


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dosage compensation

a genetical mechanism in which ALLELES of a gene automatically regulate the amount of a useful product produced, so that homozygous-dominant GENOTYPES produce the same amount of gene product as heterozygotes. In this way the two genotypes cannot be distinguished. Dosage compensation occurs regularly in female mammals where one X-chromosome in each cell is thought to become inactivated, leading to equal amounts of gene products in males and females. See INACTIVE-X HYPOTHESIS.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Studies on gene dosage compensation in the allotriploid endemic Iberian minnow showed that the allelic expression patterns differ between genes and between different tissues [20].
Absence of Sxl is associated with upregulation of genes on the single X chromosome (dosage compensation), male somatic development, and male germ line development.
"Strict dosage compensation of all genes on the chromosome isn't necessary," concludes study coauthor Laura Carrel.