dorzolamide


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dorzolamide

 [dor-zo´lah-mīd]
a carbonic acid anhydrase inhibitor, used in treatment of open-angle glaucoma and ocular hypertension; administered topically to the conjunctiva as the hydrochloride salt.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

dorzolamide

A CARBONIC ANHYDRASE inhibitor drug used in the form of eyedrops to treat open angle GLAUCOMA. A brand name is Trusopt.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

carbonic anhydrase inhibitors 

Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann
References in periodicals archive ?
(14) Other combination medications are available in a single bottle, such as Cosopt, which contains the beta-blocker timolol and a carbonic anhydrase inhibitor (dorzolamide).
Local data on the efficacy of combination of Latanoprost and Timolol was not available however few local studies on combination of Dorzolamide and Timolol have revealed a reduction of IOP by 27-30% which is almost equal to that achieved with Latanoprost alone18,19.
Supplies of timolol (Timoptol), dorzolamide (Trusopt) and dorzolamide with timolol (Cosopt) preservative-free products were affected but MSD's preservative-free prostaglandin analogue tafluprost (Saflutan) was not, owing to a different source of manufacture (Santen Pharmaceutical).
has been given final approval for dorzolamide and timolol ophthalmic solution.
Visual acuity of the patient was 2/10 in both eyes and he had been under topical dorzolamide treatment 3 times a day for nearly a year without any change in VA.
Many topical ocular hypotensive agents are available to counter this side effect of which the routinely used medications include topical beta blockers (0.25-0.50% timolol maleate, 0.25-0.50% levobunalol, 0.25% betoxalol), topical alpha 2- agonists (1% apraclonidine HCL, 0.2% brimonidine tartrate), topical carbonic anhydrase inhibitors (2% dorzolamide, 1% brinzolamide) and topical prostaglandin analogs (0.005% latanoprost, 0.004% travoprost, 0.03% bimatoprost)7.
She has been using guttae Dorzolamide 2% twice daily, Brimonidine tartrate 0.1% twice daily, and Latanoprost 0.005% nocte in both eyes during this time.
* April 2008--Hi-Tech Pharmacal was granted tentative approval for dorzolamide hydrochloride with timolol maleate ophthalmic solution.
evaluated the conjunctival changes in bulbar conjunctival impression cytology specimens from patients receiving timolol, latanoprost, dorzolamide, timolol + latanoprost, and timolol + dorzolamide medications according to Nelson's method.
Dorzolamide hydrochloride/timolol maleate ophthalmic solution is a combined preparation of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent, each reducing IOP by a different mechanism8.