24, 26) We have shown that BDNF may cause downregulation of the chloride transporter KCC2 in a subpopulation of lamina I secondary sensory neurons in dorsal horn
, which then causes a depolarizing shift in the anion reversal potential ([E.
Western blotting results showed that FGFR3 and GFAP expression was significantly increased in the spinal dorsal horn
of SNI rats.
sup] Specifically, ERK activation in spinal cord dorsal horn
neurons occurs by nociceptive activity by regulating the activity of glutamate receptors and potassium channels, as well as inducing gene transcription.
Effects on dorsal horn
convergent neurons in the rat.
Formalin, when injected in the hind paw, is known to increase c-Fos expression in the spinal dorsal horn
ipsilateral to the injection site.
Finally, inhibition is caused by the use of drugs that prevent the release of neurotransmitters in the dorsal horn
required for pain transmission.
Downregulation of M4 but not M2 muscarinic receptors in the dorsal horn
after peripheral nerve injury relates to responsiveness to SCS.
Prolonged primary afferent induced alterations in dorsal horn
neurones, an intracellular analysis in vivo and in vitro.
In chronic pain models, there is a decrease in the number of opioid receptors in the dorsal horn
of the spinal cord at the level of the injury but an increase in the number of [CB.
After removing the receptor protein from the dorsal horn
, the itch was stopped and there was no impact on any other sensory sensations, such as pain, touch and temperature, meaning they had found the biocircut that causes itchy feelings.
The cells were distributed mainly in the dorsal horn
It features increased excitation at the level of the dorsal horn
nuclei and inhibition of descending pathways responsible for diffuse noxious inhibitory control.