Inhibition of the pain signal will occur if other, stronger signals arrive at the dorsal horn
at the same time, which is the theory behind massage therapies and transcutaneous electrical nerve stimulation (TENS).
Prolonged primary afferent induced alterations in dorsal horn
neurones, an intracellular analysis in vivo and in vitro.
These data suggested that OMT could successfully prevent CCI-induced mechanical allodynia in the spinal dorsal horn
through blocking NMDAR, more precisely, NR2B-containing NMDAR.
In chronic pain models, there is a decrease in the number of opioid receptors in the dorsal horn
of the spinal cord at the level of the injury but an increase in the number of [CB.
The GABA-ir neurons were concentrated primarily in the dorsal horn
of each ganglion, and the number of GABA-ir neurons was approximately 25 cells per section.
Next, the researchers set up a test to see which of the abnormally altered metabolites in dorsal horn
tissue could evoke signs of pain signalling in cultures of rat spinal cord tissue.
Intrathecal or epidural fentanyl acts mainly on neurons with opioid receptors in lamina III of the dorsal horn
and laminae V and VII, producing a segmental antinociceptive effect (28).
Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn
Receptors in the skin, communicate with the spinal nerves through the dorsal horn
in the spinal cord.
Using a dorsal root ganglion (DRG) and dorsal horn
(DH) coculture system as a model for the first sensory synapse in the CNS, we studied menthol effects on sensory synaptic transmission and the underlying mechanisms.
Tissue damage will stimulate nociceptors and generate an action potential, which is transmitted by thin myelinated Aa fibres and unmyelinated C fibres (both are called primary afferents) to the dorsal horn
in the spinal cord.
Somatic afferent neurons firing in the spinal cord can inhibit viscerosomatic neurons in the dorsal horn
from responding to stimuli.