For the stab injury to the dorsal funiculus, the trace of the needle tract and accompanying damage to the dorsal column were revealed by the eriochrome cyanine R staining (Figure 3(d)).
To determine whether a breakdown of BBB within the regions of immunological demyelination induced astrogliosis, we first created a region of immunological demyelination in the dorsal column and then 24 h later an hemisection or a stab injury was performed.
In animals that received a stab injury without previous immunological demyelination, GFAP stainedtransversesectionsrevealedadense population of distal hypertrophic reactive astrocytes intensely expressing GFAP in the dorsal column 1mm rostral (Figure 5(d)) to the injury epicenter (Figure 5(b)).
Dorsal columns and demyelinated regions were delineated using cryostat-sectioned tissue stained with eriochrome cyanine R for myelin.
Five years ago, however, the Galveston researchers uncovered evidence that the bulk of the pain from the internal organs, or viscera, travels up the overlooked dorsal column, while the spinothalamic tract carries pain messages predominantly from the skin and muscles.
By then, Hirshberg was convinced that a visceral pain pathway lurked somewhere in the dorsal column.
When he cut the dorsal column, however, Al-Chaer practically abolished the neurons' response.
Cutting the dorsal column may rid patients of more than just pain, she suggests.
DREZ lesioning is offered if the injury involves the dorsal columns
. If these are intact, SCS is suggested.
I would write if I discovered sensory or motor nerve deficit particularly in her trigeminal nerve, dorsal columns, or spinothalamic tract.
* A clinical neurologist could monitor the progress of damage to her dorsal columns and peripheral sensory deficit to avoid ulcer formation, which could lead to loss of the limb.