dopamine transporter


Also found in: Acronyms, Wikipedia.

dopamine transporter (DAT),

a protein, found, for example, in the terminal of a presynaptic neuron, which decreases the concentration of dopamine near the synapse by effecting its reuptake into the presynaptic neuron.
References in periodicals archive ?
Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms.
Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.
Niznik, "Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis," FASEB Journal, vol.
[24] Parkinson Study Group, "Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression," JAMA, vol.
Lack of association between the dopamine transporter gene 3' VNTR polymorphism and attention deficit hyperactivity disorder in Chinese Han children: case-control and family-based studies.
Immunohistochemistry Assays for Tyrosine Hydroxylase (TH) and Dopamine Transporter (DAT) in Striata.
Hall et al., "Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: Prominent effects of dopamine transporter deletions," Behavioural Pharmacology, vol.
Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates.
In this study, we aimed to assess the function of presynaptic dopaminergic neurons in patients with mRT by dopamine transporter positron emission tomography (DAT-PET) and to evaluate the utility of clinical features or electrophysiological studies in differential diagnosis.
Nihon Medi-Physics markets the brain disorder diagnostic agent DaTSCAN Injectable (ioflupane [123I], "DaTSCAN"), which is the only product indicated for the use of dopamine transporter scintigraphy in diagnosing DLB in Japan.
The dopamine transporter (DAT) belongs to the SLC6A family of secondary-active [Na.sup.+]/Cl-dependent neurotransmitter transporters and functions to terminate dopaminergic signaling through re-uptake of dopamine (DA) from the synapse (1-3) (1).