It was around the time of this recognized failure that the one researcher made the first formal articulation of the dopamine hypothesis of schizophrenia (Rossum, 1966).
In the wake of the success of the dopamine hypothesis of schizophrenia, speculative hypotheses failing to proffer empirical support received little attention in research.
Antipsychotic drugs work by modulating dopaminergic neurotransmission, and by doing so, they provide powerful evidence for the dopamine hypothesis of psychosis (Howes & Kapur, 2009).
After a lengthy review of the evidence for and against the dopamine hypothesis, one psychiatrist proposed that antipsychotics primarily work not by modifying dopamine but instead by inducing neurocognitive suppression, which diminishes the severity of psychotic symptoms (Moncrieff, 2009).
Historical development of the dopamine hypothesis of schizophrenia.