dopa


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Related to dopa: dopamine, DOPA decarboxylase

dopa

 [do´pah]
a compound produced by oxidation of tyrosine by tyrosinase; it is the precursor of dopamine and an intermediate product in the biosynthesis of norepinephrine, epinephrine, and melanin. The naturally occurring form is l-dopa (see levodopa), and is used to treat parkinson's disease and other forms of parkinsonism.

do·pa

, DOPADopa (dō'pă),
An intermediate in the catabolism of l-phenylalanine and l-tyrosine, and in the biosynthesis of norepinephrine, epinephrine, and melanin; the l form, levodopa, is biologically active. See: dopa reaction.
Synonym(s): 3, 4-dihydroxyphenylalanine

dopa

/do·pa/ (do´pah) 3,4-dihydroxyphenylalanine, produced by oxidation of tyrosine by monophenol monooxygenase; it is the precursor of dopamine and an intermediate product in the biosynthesis of norepinephrine, epinephrine, and melanin. -dopa is the naturally occurring form; see levodopa.

dopa

(dō′pə)
n.
An amino acid, C9H11NO4, that occurs widely in animals and plants. In humans and other mammals, it is formed in the liver from tyrosine and converted to dopamine in the brain.

dopa

[dō′pə]
an amino acid, produced by oxidation of tyrosine, that occurs naturally in plants and animals. It is a precursor of dopamine, epinephrine, norepinephrine, and melanin. See also dopamine hydrochloride, levodopa.

do·pa

, DOPA (dō'pă)
An intermediate in the catabolism of l-phenylalanine and l-tyrosine, and in the biosynthesis of norepinephrine, epinephrine, and melanin; the l form, levodopa, is biologically active.

DOPA (dihydroxy phenylalanine)

a precursor in the biochemical PATHWAY leading to MELANIN formation in animals. DOPA is not metabolized in individuals with ALBINISM.

DOPA

The common name for a natural chemical (3, 4-dihydroxyphenylalanine) made by the body during the process of making melanin.
Mentioned in: Albinism

do·pa

, DOPA (dō'pă)
Intermediate in catabolism of l-phenylalanine and l-tyrosine and in biosynthesis of norepinephrine, epinephrine, and melanin.

dopa

(dō´pə),
n an amino acid derived from tyrosine that occurs naturally in plants and animals. It is a precursor of dopamine, epinephrine, and norepinephrine.

dopa

L-3,4-dihydroxyphenylalanine. Key intermediate in two pathways; the production of melanins from tyrosine catalyzed by the copper-containing enzyme, tyrosinase, to produce dopa, or the biosynthesis of catecholamines catalyzed by the action of tyrosine. It is used in manganese poisoning. Called also L-dopa and levodopa.
References in periodicals archive ?
Isao, Synthesis of L- Dopa from L-tyrosine by Aspergillus oryzae, J.
Freire, L- Dopa Production by Immobilized Tyrosinase, Appl.
Our histochemical and immunohistochemical methods have also showed that, unlike DOPA residues, which are uniformly distributed in the secretory granules of both types of cement cells, pSer residues appear to be present mostly in the inclusions of the heterogeneous granules.
The contribution of DOPA to substrate--peptide adhesion and internal cohesion of mussel-inspired synthetic peptide films.
The same group and others have used the method to characterize the neurochemical profiles of dopamine-|3hydroxylase deficiency, DOPA decarboxylase deficiency, tyrosine hydroxylase deficiency, Menkes disease, and X-linked deficiencies of monoamine oxidase.
4] Nonstandard abbreviations: LCED, liquid chromatographic electrochemical detection; DHPG, dihydroxyphenylglycol; DOPA, dihydroxyphenylalanine; DOPAC, dihydroxyphenylacetic acid.
The responses of conch larvae to hydrogen peroxide, DOPA, vanadate, and GABA are consistent with the known roles of second messenger pathways in settlement and metamorphosis, as well as with the known activities of these compounds in other systems.
To investigate DOPA's role, Deming's group synthesized model proteins containing 5 percent DOPA and the rest glutamic acid.
Several methods have been developed for the analysis of dopa in plasma (3).
Determination of free DOPA and 3-O-methyl-DOPA in human plasma by high-performance liquid chromatography with electrochemical detection.
Measuring L-dopa in plasma and urine to monitor therapy of elderly patients with Parkinson's disease treated with L-dopa and a dopa decarboxylase inhibitor.
They all rely on proteins that contain an amino acid called "Dopa," (identical to the Dopa used to treat Parkinson's disease), and have been studied extensively by Waite and his research group.