donepezil


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donepezil

 [do-nep´ĕ-zil]
a reversible acetylcholinesterase inhibitor, used as the hydrochloride salt for treatment of mild to moderate symptoms of dementia of the Alzheimer type; administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

donepezil

(dō-nĕp′ə-zĭl′)
n.
A drug, C24H29NO3, that inhibits acetylcholinesterase and is used in its hydrochloride form to treat mild to moderate dementia caused by Alzheimer's disease.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

donepezil

Aricept® Neurology A cholinesterase inhibitor used to maintain cognition in Alzheimer's disease Contraindications Succinylcholine-type anesthesia, sick sinus syndrome, seizures Adverse events N&V, insomnia, muscle cramps, anorexia, fatigue. See Alzheimer's disease.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

donepezil

An ACETYLCHOLINESTERASE inhibitor drug used in Alzheimer's disease and other forms of dementia to increase the amount of ACETYLCHOLINE available for nerve transmission. A brand name is Aricept.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Donepezil

A drug commonly prescribed for Alzheimer's disease that provides temporary improvement in cognitive functions for some patients with mild-to-moderate forms of the disease.
Mentioned in: Dementia
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Free radical scavenging activity of donepezil was determined by DPPH assay method as per Yohozowa et al.
By analyzing HRV and electrocardiogram parameters, we determined whether donepezil is associated with an increased risk of bradycardia and ventricular arrhythmia.
Donepezil, as a strong hydrophobic drug, can be loaded into the hydrophobic center of CHP NPs to form a donepezil nanopreparation (DZP-CHP).
Donepezil has been shown to attenuate scopolamine-induced reduction of the P300 amplitude, which is consistent with the modulation of P300 by donepezil in AD Alzheimer's patients [49].
In addition, short-term improvement in odour identification from baseline to eight weeks tended to predict longer-term cognitive improvement with donepezil treatment over one year.
Indian pharmaceutical firm Zydus Cadila (NSE: CADILAHC) has been granted final approval from the US Food and Drug Administration (FDA) to market Donepezil Hydrochloride tablets in the strength of 23 mg, the company said on Friday.
Among 44 patients, 15 (34%) were on memantine and donepezil combination therapy and they reported to have some side effects such as insomnia, hallucinations, urinary incontinence and fatigue (Table 2).
Acetylcholinesterase from electric eel ([greater than or equal to]1000 units/mg protein), acetylcholine chloride (AChCl), acetylthiocholine chloride (ATChCl), 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), donepezil hydrochloride monohydrate, galanthamine hydrobromide, tetraisopropyl pyrophosphoramide (iso-OMPA), phosphate buffer saline (PBS) pH 7.4, dimethyl sulfoxide (DMSO), and isopropyl alcohol were purchased from Sigma-Aldrich (St.
Donepezil is a reversible inhibitor of acetylcholinesterase (AChE), the break-down enzyme of acetylcholine (ACh) [15].
Patients with moderate to severe AD receiving stable doses of both donepezil and memantine experienced limited cognitive improvement [10].
Donepezil is a specific and reversible inhibitor of acetylcholinesterase (Ach), which increases the bioavailability of acetylcholine, a neurotransmitter present in the peripheral central nervous system.