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The name of a sheep famous for being the first mammal cloned from an adult somatic cell. Dolly was grown from an egg, the nucleus of which had been replaced with the DNA from the mammary tissue of a six-year-old ewe


the first mammal, a sheep, to be created by the cloning of an adult cell by NUCLEAR TRANSFER (see also ASEXUAL REPRODUCTION). The nucleus from a quiescent (see QUIESCENCE), adult udder cell of a finn Dorset ewe was transferred into an unfertilized OVUM from which the nucleus had been removed i.e. an enucleate OOCYTE, of a Scottish Blackface ewe. Electric current was applied to induce EMBRYO formation and the embryo introduced into a surrogate Blackface ewe. The process was repeated 276 times.

A lamb was born, called Dolly, to the Blackface ewe, but with almost identical genetic make-up to the finn Dorset ewe from which the genetic material derived.

The creation of Dolly demonstrated that adult cells could be reprogrammed for embryo development.

Dolly developed ARTHRITIS at the relatively young age of 5.5 years, and at 6 years was euthanased, due to development of a progressive lung disease. Whether this was a consequence of the cloning process is unknown.

References in periodicals archive ?
Regulars toast the arrival of dollybird teacher Sandra Kelly, played by Michelle Costello, to Killinaskully
We're not just talking about the shortness of the office dollybird's skirt or the amount of cleavage glimpsed on a well-known man-eater visiting on business.
Instead, I roared home Linda's two-year-old Shatin Dollybird from a bar 2000 miles away on the Costa Crime.
In reality, it became a nature v nurture tussle, but the fact that Prasad is a scientist and not another dollybird dimwit was the programme's saviour.
Sharon is the goodtime girl in a miniskirt, the dollybird behind the checkout who clocks off and goes for lunch with her friends, Tracey and Michelle.
The 5-2 favourite appeared to have lost her chance when drifting to the centre and narrowly conceding the lead to the rail runner Shatin Dollybird.
And he added, cuttingly: 'What I think it means is that somebody who may not be particularly good-looking, middle aged, a woman, may not get a chance because they may think, hold on, she's not a dollybird.'
With the ever-reliable Richy Thompson also at the double and Keith Johnston added to the options after joining from Newry City AFC, confidence is starting to coarse through Dollybird veins again.
The Dollybird goals came from four different sources - Redpath, Gourley, Johnston and Cunningham - to earn them a trip to near neighbours Banbridge Rangers.
Recent inductees include the USWheel of Fortune dollybird Vanna White, tweeny nonentities Mary Kate and Ashley Olsen (stars of the 1995 classic You're Invited To Mary-Kate And Ashley's Sleepover Party) and Pee Wee Herman.
The Cree Lodge handler struck in the juvenile event with Shatin Dollybird partnered by crack apprentice Tony Beech.
Linda Perratt's Shatin Dollybird may have to play second fiddle to Alan Berry's newcomer, Gazette It Tonight (7.0).