Dolly

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The name of a sheep famous for being the first mammal cloned from an adult somatic cell. Dolly was grown from an egg, the nucleus of which had been replaced with the DNA from the mammary tissue of a six-year-old ewe

Dolly

the first mammal, a sheep, to be created by the cloning of an adult cell by NUCLEAR TRANSFER (see also ASEXUAL REPRODUCTION). The nucleus from a quiescent (see QUIESCENCE), adult udder cell of a finn Dorset ewe was transferred into an unfertilized OVUM from which the nucleus had been removed i.e. an enucleate OOCYTE, of a Scottish Blackface ewe. Electric current was applied to induce EMBRYO formation and the embryo introduced into a surrogate Blackface ewe. The process was repeated 276 times.

A lamb was born, called Dolly, to the Blackface ewe, but with almost identical genetic make-up to the finn Dorset ewe from which the genetic material derived.

The creation of Dolly demonstrated that adult cells could be reprogrammed for embryo development.

Dolly developed ARTHRITIS at the relatively young age of 5.5 years, and at 6 years was euthanased, due to development of a progressive lung disease. Whether this was a consequence of the cloning process is unknown.

References in periodicals archive ?
Was dressing as a 1960s dolly bird official health and safety rules back then?
The performances are uniformly excellent, with Geraghty leading a fine eight-strong cast featuring Tracy Shaw (Claire Marshall), Martyn Standbridge (Richard Marshall), Paul Lavers (Baxter), Jez Edwards (Goddard), Michelle Morris (Marion Selby), Paul David-Gough (Robert Westerby) and Gemma Bissix as Vicki Reynolds, a '60s dolly bird with a Barbara Windsor-esque giggle.
One minute Leslie Ash, above, was raising laughs as comedy's leading dolly bird, the next she was a national figure of fun.
But she's not some dolly bird with a spray tan and a cleavage you could ski down.
Most laughable was the sex scene in a nightclub toilet between Jason and some Northern dolly bird, although fair play (award) to Jason for pulling the porno faces and making the porno noises to go with his porno goatee beard.
Carol made the huge transition from decorative dolly bird to mainstream TV by going back to her natural hair colour and working without pay.
Yes, Gemma, arrogant young millionaire footballers, who could bag a different dolly bird every night of the week, love nothing more than women who cease to make any effort once they have their feet under the table and whose idea of a good time is staying in scoffing chips.
We did find it funny that at my age they thought I had just had a baby - if they're right I must've had a dolly bird that my wife didn't know about somewhere
Urging the brothers on are Tom's dolly bird fiancee, Shirley and Terry's tough-talking wife, Karen.
Despite the presence of Adam Faith, dolly bird Suzanne Sommers, and former Scottish international Frank McLintock as "football adviser", the movie was described as "irresistibly bad".
Alf didn't have a flash dolly bird in the box with him.