Dolly

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The name of a sheep famous for being the first mammal cloned from an adult somatic cell. Dolly was grown from an egg, the nucleus of which had been replaced with the DNA from the mammary tissue of a six-year-old ewe

Dolly

the first mammal, a sheep, to be created by the cloning of an adult cell by NUCLEAR TRANSFER (see also ASEXUAL REPRODUCTION). The nucleus from a quiescent (see QUIESCENCE), adult udder cell of a finn Dorset ewe was transferred into an unfertilized OVUM from which the nucleus had been removed i.e. an enucleate OOCYTE, of a Scottish Blackface ewe. Electric current was applied to induce EMBRYO formation and the embryo introduced into a surrogate Blackface ewe. The process was repeated 276 times.

A lamb was born, called Dolly, to the Blackface ewe, but with almost identical genetic make-up to the finn Dorset ewe from which the genetic material derived.

The creation of Dolly demonstrated that adult cells could be reprogrammed for embryo development.

Dolly developed ARTHRITIS at the relatively young age of 5.5 years, and at 6 years was euthanased, due to development of a progressive lung disease. Whether this was a consequence of the cloning process is unknown.

References in periodicals archive ?
It was lovely to speak to Sue but I sensed unhappiness at the "dolly bird" tag.
I was having a bath when my husband suddenly took off his clothes, got in with me and told me he was having an affair with an East European dolly bird off the internet
"I'm not just the dolly bird" - Presenter Tess Daly (pictured), insisting that her role in Strictly Come Dancing is far more important than merely looking pretty.
Thankfully the dolly bird had a decent weapon to defend herself with.
As a make-up artist you are treated as a bit of a dolly bird and people think you are not very bright.
But, like this lady said, if you are a young dolly bird with a buggy, no problem whatsoever!
Women loved her as Sandra, the wannabe posh Scouse girl r who put the dolly bird into The Livei r Birds.
Alf didn't have a flash dolly bird in the box with him.
"He was a man who had his job, which he coped with, but a claustrophobic, over-smothering bingo loving mum and argumentative in-laws." He had a domineering boss, too, in inspector Blakey and there was only limited respite - the bus canteen and the pub and the chance of a night out with a 'dolly bird'.
But when a dolly bird came to the counter I left pretty quick.
"She's a dolly bird so I had rollers in the hair, loads of make-up and real Chanel suits.
Directed by David Pountney and designed by Robert Innes Hopkins, it features a jumbled blend of giant faces on screens, alien-like sailors, dolly bird village girls, a recurring image of a giant eye, and astronauts - yes, astronauts!