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The name of a sheep famous for being the first mammal cloned from an adult somatic cell. Dolly was grown from an egg, the nucleus of which had been replaced with the DNA from the mammary tissue of a six-year-old ewe


the first mammal, a sheep, to be created by the cloning of an adult cell by NUCLEAR TRANSFER (see also ASEXUAL REPRODUCTION). The nucleus from a quiescent (see QUIESCENCE), adult udder cell of a finn Dorset ewe was transferred into an unfertilized OVUM from which the nucleus had been removed i.e. an enucleate OOCYTE, of a Scottish Blackface ewe. Electric current was applied to induce EMBRYO formation and the embryo introduced into a surrogate Blackface ewe. The process was repeated 276 times.

A lamb was born, called Dolly, to the Blackface ewe, but with almost identical genetic make-up to the finn Dorset ewe from which the genetic material derived.

The creation of Dolly demonstrated that adult cells could be reprogrammed for embryo development.

Dolly developed ARTHRITIS at the relatively young age of 5.5 years, and at 6 years was euthanased, due to development of a progressive lung disease. Whether this was a consequence of the cloning process is unknown.

References in periodicals archive ?
| The book The Wooden Dollies of North Shields is priced PS5 and can be bought at North Shields library and the Keel Row bookshop in the town.
Dollies & Boxes Unlimited provides moving and packaging solutions for commercial and residential customers and is Toronto's ultimate resource for storage and moving boxes, bubble, floor runners, dollies and other accessories and equipment needed for a successful move.
An infeed crane simultaneously collects up to eight carts or dollies from the infeed buffer channels and conveys them to a flow-through storage rack where the crane pushes them into storage lanes.
Fully loaded carts and dollies enter the rack and are pushed forward into the channel by the infeed crane.
Dollies & Boxes Unlimited services a wide-range of business customers and offers moving and packaging solutions for University students, those seeking out home-storage and moving options.
Whether bottles or cans, shrink packs, pad shrink packs, tray shrink packs, or multipacks--everything is possible- and simple handling of dollies at the point of sale is guaranteed.
The KHS dolly system solutions begin with the unstacking of dollies provided or separately stacked on a carrier pallet into a special magazine.
The pub dolly, paid for by Samuel Smith's brewery, was installed 14 years ago near the spot where many dollies have stood over the years.
At the time of going to press, over fourty high-volume lines were being merchandised on dollies in Tesco.
Available in all standard colours the dollies can be supplied with company names printed on the side.