dofetilide


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dofetilide

 [do-fet´ĭ-līd]
an antiarrhythmic that prolongs the duration of the cardiac action potential and the effective refractory period without affecting conduction velocity; used in the treatment of atrial arrhythmias, administered orally.

dofetilide

/do·fet·i·lide/ (do-fet´ĭ-līd) an antiarrhythmic used in the treatment of atrial arrhythmias.

dofetilide

a class III antidysrhythmic.
indications It is used to treat atrial fibrillation and flutter.
contraindications Known hypersensitivity to this drug, digitalis toxicity, aortic stenosis, pulmonary hypertension, QT syndromes, and severe renal disease prohibit its use. It is also contraindicated in children.
adverse effects Serious adverse effects include severe diarrhea, anorexia, angina, premature ventricular contractions, substernal pressure, transient hypertension, and precipitation of angina. Common side effects include syncope, dizziness, nausea, vomiting, hypotension, postural hypotension, and bradycardia.

dofetilide

Tikosyn® Cardiology A selective potassium channel blocking antiarrhythmic used in CHF and left ventricular dysfunction to convert A Fib, prevent its recurrence, and ↓ risk of future hospitalization; it has no effect on mortality Contraindications Succinylcholine-type anesthesia, sick sinus syndrome, seizures Adverse events Torsade de pointes. See Atrial fibrillation.
References in periodicals archive ?
It is notable that methadone is the second most frequent cause of drug arrhythmia after dofetilide (Kao et al.
The launch of doxycycline hyclate IR tablets is Mayne Pharma's fourth first-to-market generic launch since June last year after dofetilide capsules, butalbital acetaminophen tablets (50 mg/300 mg) and methylphenidate extended-release capsules f60 mg).
The use of these drugs (such as propafenone, dofetilide, and amiodarone) has been limited by proarrhythmic and noncardiovascular toxicities as well as modest antiarrhythmic efficacy.
5 mg/hr for 18 hr Dofetilide Oral: 125 to 500 meg q12 hr 125-500 meg q 12 hr.
received approval from the FDA to market dofetilide capsules, a generic alternative to Tikosyn, an anti-arrhythmic agent used to treat irregular heartbeats, such as atrial fibrillation and atrial flutter.
For patients who achieve sinus rhythm, there are several choices of antiarrhythmic agent to be considered for a rhythm-control strategy, including amiodarone, dofetilide, dronedarone, flecainide, propafenone, and sotalol.
Drug Interactions: Co-administration of cisapride, pimozide, quinidine, dofetilide, levacetylmethadol (levomethadyl), felodipine, oral midazolam, nisoldipine, triazolam, lovastatin, simvastatin, ergot alkaloids such as dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) or methadone with ONMEL[TM] is contraindicated.
Until relatively recently, the only method of choice has been antiarrhythmic medications: amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), dronedarone (Multaq), flecainide (Tambocor), propafenone (Rhythmol), and sotalol (Betapace).
Table 1--Causes of Long QT Syndrome Congenital Acquired Inherited Metabolic chairnelopathies Roman o-Ward Hypocalcernia, Syndrome hypokalemia, hypomagnesemia Jervell and Lange-Nielsen Syndrome Idiopathic Anti-Arrytbmics Amiodarone, Diospyramide, Dofetilide, ibutilide, Quinidine, Procainamide, Sotalol Antibistarnines Asteinizole, Terfenidine Anti-Infectives Clan thromycin, Erythrornycin, Pentamidine, Sparfi oxcin Anti-Malarial Chioroquine, Halofantrinc Psychotropics Chiorprornazine, Flaloperidol, Thioridazone, SSRIs Heart Disease Left ventricular hvpertrop hy, heart failure, invocardial isehemia
4) Rate control was achieved with beta-blockers with or without digitalis, and rhythm control was maintained by cardioversion, amiodarone, sotalol, or dofetilide.
The newer antiarrhythmics like dofetilide and ibutilide are more potent as well as highly selective for [K.