Drug Interactions: Co-administration of cisapride, pimozide, quinidine, dofetilide
, levacetylmethadol (levomethadyl), felodipine, oral midazolam, nisoldipine, triazolam, lovastatin, simvastatin, ergot alkaloids such as dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) or methadone with ONMEL[TM] is contraindicated.
Table 1--Causes of Long QT Syndrome Congenital Acquired Inherited Metabolic chairnelopathies Roman o-Ward Hypocalcernia, Syndrome hypokalemia, hypomagnesemia Jervell and Lange-Nielsen Syndrome Idiopathic Anti-Arrytbmics Amiodarone, Diospyramide, Dofetilide
, ibutilide, Quinidine, Procainamide, Sotalol Antibistarnines Asteinizole, Terfenidine Anti-Infectives Clan thromycin, Erythrornycin, Pentamidine, Sparfi oxcin Anti-Malarial Chioroquine, Halofantrinc Psychotropics Chiorprornazine, Flaloperidol, Thioridazone, SSRIs Heart Disease Left ventricular hvpertrop hy, heart failure, invocardial isehemia
4) Rate control was achieved with beta-blockers with or without digitalis, and rhythm control was maintained by cardioversion, amiodarone, sotalol, or dofetilide
The most potent QT-prolonging medications are antiarrhythmic agents, particularly amiodarone, dofetilide
, quinidine, and sotalol, with quinidine possibly having the most torsadogenic potential.
The newer antiarrhythmics like dofetilide
and ibutilide are more potent as well as highly selective for [K.
in patients with congestive heart failure and left ventricular dysfunction.
Proarrhythmia is observed in patients treated with drugs that block the hERG channel, including quinidine, dofetilide
, antihistamines, and antibiotics (Bednar et al.
Chemical cardioversion of atrial fibrillation with intravenous dofetilide
Itraconazole should not be prescribed to patients who are taking cisapride, pimozide, quinidine, dofetilide
Previously, the seven drugs listed were dofetilide
, sotalol, quinidine, thioridazine, moxifloxacin, pimozide, and sparfloxacm.
Contraindication: TIVICAY is contraindicated (1) in patients with previous hypersensitivity reaction to dolutegravir, and (2) in patients receiving dofetilide
(antiarrhythmic) due to the potential for increased dofetilide
plasma concentrations and the risk for serious and/or life-threatening events.
3 years) were allocated to receive antiarrhythmic drugs, including fle-cainide (Tambocor), propafenone (Ryth-mol), dronedarone (Multaq), amiodarone (Cordarone), dofetilide
(Tikosyn), and sotalol (Betapace).