Several reports have stated that CrkII preferentially activates the small GTPase Rac1 through DOCK180, a guanine-nucleotide exchange factor, and this regulation is achieved by the formation of a multiple protein complex with docking protein
p130Cas [32, 33].
Human enhancer of filamentation 1, a novel p130cas-like docking protein
, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.
Activation of the INS receptor triggers phosphorylation of tyrosine residues and subsequent activation of the INS docking proteins (INS receptor substrates 1 and 2; IRS-1, IRS-2).
We hypothesized that the SIT may exert its effect through insulin metabolic signaling molecule, p70 ribosomal S6K1, and through phosphorylation of INS docking proteins IRS-1 and IRS-2.
This improvement was associated with the protective effect of [beta]-cell function by reductions of mTOR/S6K1 activation, degradation, and serphorylation of INS docking proteins IRS-1 and IRS-2.
The purpose of these docking proteins
is to take information received at the cell's surface and broadcast it throughout the rest of the cell.