divided dose


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dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

di·vid·ed dose

a definite fraction of a full dose; given repeatedly at short intervals so that the full dose is taken within a specified period, usually 1 day.
Synonym(s): fractional dose

di·vid·ed dose

(di-vīd'ĕd dōs)
A definite fraction of a full dose; given at shorter intervals than a full dose.

di·vid·ed dose

(di-vīd'ĕd dōs)
Definite fraction of a full dose; given repeatedly at short intervals so that the full dose is taken within a specified period, usually 1 day.
Synonym(s): fractional dose.
References in periodicals archive ?
When the patient began to experience sedation, his gabapentin dosage was decreased to 500 mg/day in divided doses.
Order 3 mg/kg per day in three divided doses for 5 of every 21 days.
After a 1-week single-blind placebo lead-in period, patients in the divalproex arm added 750 mg of the drug daily in divided doses to their other medications.
Briggs recommended checking serum levels and maternal renal function frequently in pregnant women on prolonged gentamicin therapy To minimize high levels of this agent in the mother and, thus, in the fetus, avoid single-dose therapy and administer the daily dose in divided doses.
Forty-two patients (mean age, 40.5 years) with major depressive disorder, whose diet contained no more than 3 g per day of total omega-3 fatty acids, received 20 mg per day of citalopram (a selective serotonin-reuptake inhibitor) and were randomly assigned to receive omega-3 fatty acids (1.8 g per day of eicosapentaenoic acid and 0.4 g per day of docosahexaenoic acid, in 2 divided doses per day) or placebo (olive oil) for 8 weeks.
Recommended dosing for children consists of 14 days of amoxicillin at 50 mg/kg per day in three divided doses (maximum 500 mg per dose); cefuroxime at 30 mg/kg per day in two divided doses (max 500 mg per dose); or--if the child is older than 8 years--oxycycline at 4 mg/kg per day in two divided doses (maximum 100 mg per dose).
A second Novartis-sponsored study showed that genital herpes lesions could be halted at the papule stage in about one of every four patients taking 1,000 mg of famciclovir in divided doses during the first day they recognized prodromal symptoms.
Patients treated with glycerol received a dosage of 6.0 g/kg daily, given orally in four divided doses. Patients who received dexamethasone were given a dosage of 0.6 mg/kg daily, administered intravenously in four divided doses.
Dosage: 400 mg a day in two divided doses (for age 17 and over).
Infants under 10 pounds can take 500 mg daily in some fruit juice, while babies between 10 and 20 pounds could take anywhere from 500 mg to 1000 mg total per day, in divided doses. Older children can take 1000 mg daily per year of life (5000 mg for a 5 year-old child, for example, in divided doses).
The dose can be increased to 100 mg/day, given as two 25-mg pills in the morning and two 25-mg pills in the evening if there is no response within a week, but the doses should not exceed 200 mg/day in divided doses, Dr.
The double-blind, placebo-controlled, 8-week trial involved 228 patients randomized to receive either placebo or 4.5 g, 6 g, or 9 g sodium oxybate per night in two equally divided doses at bedtime and from 2 1/2 to 4 hours later.