In a double-blind, placebo-controlled study, 30 adolescents in a bipolar I manic or mixed episode initially received
divalproex, 20 mg/kg/d, then were randomly assigned to 6 weeks of adjunctive quetiapine, titrated to 450 mg/d in 7 days (n=15), or placebo (n=15).
Divalproex in the treatment of bipolar depression: a placebo-controlled study.
(13) Similarly, lithium and valproic acid (
divalproex sodium) are the pharmacotherapies of choice for mood stabilization, (2) while CBT appears to be the main psychotherapy showing benefit for patients with MS who are depressed.
Joshi et al., "A randomized controlled trial of risperidone, lithium, or
divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents," Archives of General Psychiatry, vol.
Quetiapine fumarate is indicated for schizophrenia; acute manic or mixed episodes in bipolar I disorder alone or as an adjunct to lithium or
divalproex; acute depressive episodes in bipolar disorder; maintenance treatment of bipolar I disorder, as an adjunct to lithium or
divalproex; and as an adjunctive therapy to antidepressants for the treatment of major depressive disorder.
According to the company, Seroquel XR is a once-daily tablet indicated for the treatment of schizophrenia, acute depressive episodes in bipolar disorder, acute manic or mixed episodes in bipolar disorder alone or with lithium or
divalproex, as well as an adjunctive therapy to antidepressants for patients with major depressive disorder (MDD).
(22) For relapse prevention, lithium monotherapy has been reported to be superior to
divalproex monotherapy.
For mania/hypomania, the algorithm recommends carbamazepine or
divalproex, or an atypical antipsychotic.
Divalproex sodium (Epival) 250 mg enteric coated tablets with registration no.
Treatment record showed that she had a similar but less severe episode about a year ago and had responded to a combination of oral medications that included haloperidol
divalproex sodium and diazepam on an outpatient basis.
Food and Drug Administration for prevention of adult episodic migraine (the anti-epileptics,
divalproex and topiramate, and the beta-blockers, timolol and propranolol) were found effective in a review of studies on the medications.
Two anti-seizure drugs approved for preventing migraines in adults, topiramate and
divalproex, were found to be no better than placebo in preventing childhood migraine.
