divalproex


Also found in: Dictionary, Encyclopedia, Wikipedia.

divalproex

 [di-val´pro-eks]
an anticonvulsant, used as divalproex sodium, a 1:1 compound of valproate sodium and valproic acid in treatment of migraine, manic episodes of bipolar disorder, and epileptic seizures, particularly absence seizures.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

divalproex

(dī-văl′prō-ĕks′)
n.
A combination of the drugs valproate and valproic acid, used primarily to treat mania in bipolar disorder and seizures.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

carbamazepine

An anticonvulsant used to manage partial seizures and generalised tonic-clonic seizures in children, bipolar disorder and trigeminal neuralgia; in contrast to valproate, carbamazepine is associated with better seizure control, fewer seizures and longer time to first seizure. 

Adverse effects
Dizziness, drowsiness, unsteadiness, nausea, vomiting, myelosuppression (up to 8-fold increase) in aplastic anaemia and agranulocytosis, rash, hair loss.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
In a double-blind, placebo-controlled study, 30 adolescents in a bipolar I manic or mixed episode initially received divalproex, 20 mg/kg/d, then were randomly assigned to 6 weeks of adjunctive quetiapine, titrated to 450 mg/d in 7 days (n=15), or placebo (n=15).
Clinical trials support new algorithm for treating pediatric bipolar mania: 4 atypical antipsychotics are proposed as first-line therapy, based on current evidence
Divalproex in the treatment of bipolar depression: a placebo-controlled study.
Making efficacious choices: the integration of pharmacotherapy and nonpharmacologic approaches to the treatment of patients with bipolar disorder
(13) Similarly, lithium and valproic acid (divalproex sodium) are the pharmacotherapies of choice for mood stabilization, (2) while CBT appears to be the main psychotherapy showing benefit for patients with MS who are depressed.
A mood disorder complicated by multiple sclerosis
Joshi et al., "A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents," Archives of General Psychiatry, vol.
Treatment-Emergent Mania in a Prepubertal Boy
Quetiapine fumarate is indicated for schizophrenia; acute manic or mixed episodes in bipolar I disorder alone or as an adjunct to lithium or divalproex; acute depressive episodes in bipolar disorder; maintenance treatment of bipolar I disorder, as an adjunct to lithium or divalproex; and as an adjunctive therapy to antidepressants for the treatment of major depressive disorder.
Growing generic Rx market fueled by stream of new products
According to the company, Seroquel XR is a once-daily tablet indicated for the treatment of schizophrenia, acute depressive episodes in bipolar disorder, acute manic or mixed episodes in bipolar disorder alone or with lithium or divalproex, as well as an adjunctive therapy to antidepressants for patients with major depressive disorder (MDD).
Pharmadax wins US FDA approval for generic Seroquel XR to treat schizophrenia
(22) For relapse prevention, lithium monotherapy has been reported to be superior to divalproex monotherapy.
Evidence-based treatment of bipolar disorder, bipolar depression, and mixed features
For mania/hypomania, the algorithm recommends carbamazepine or divalproex, or an atypical antipsychotic.
Behavioral symptoms in dementia need global touch
Divalproex sodium (Epival) 250 mg enteric coated tablets with registration no.
Warning aired on stolen medicine
Treatment record showed that she had a similar but less severe episode about a year ago and had responded to a combination of oral medications that included haloperidol divalproex sodium and diazepam on an outpatient basis.
Prolonged mania in a case of bipolar affective disorder
Food and Drug Administration for prevention of adult episodic migraine (the anti-epileptics, divalproex and topiramate, and the beta-blockers, timolol and propranolol) were found effective in a review of studies on the medications.
Little difference in effectiveness of drugs to prevent episodic migraine in adults
Two anti-seizure drugs approved for preventing migraines in adults, topiramate and divalproex, were found to be no better than placebo in preventing childhood migraine.
Migraine prevention in children

Medical browser ?
Full browser ?