In hospitalised patients, classic dithranol therapy with twice-daily application without immediate rinsing can easily be performed.
Maintenance or long-term therapy with dithranol is not practical and offers no advantages.
Laboratory studies showed dithranol
very quickly targeted skin cells' mitochondria ( the part of a cell from which it draws its energy ( causing the cells to die within 48 hours of using the ointment.
These include emollients (aqueous cream, emulsifying ointment), coal tar extracts, dithranol
, vitamin D derivatives (calcipotriol, tacalcitol) and the vitamin A derivative, tazarotene.
Psoriasis usually responds well to creams and ointments containing the substance dithranol
- available on prescription.
Efficacy of short-contact therapy with dithranol
in childhood psoriasis.
Hospital treatments are often based around traditional compounds such as crude coal tar and dithranol
These include coal-tar preparations Dithranol
, Calcipotriol, Tazarotene and steroid creams, or combinations such as Dovobet.
Newer preparations such as Dovonex, Calcipotriol and Curatoderm tacalcitol are less staining than coal tar products or Dithranol
in Lassar's paste, which was traditionally used.
Chodorowska G: Plasma concentrations of IFN-gamma and TNF-[alpha]lpha in psoriatic patients before and after local treatment with dithranol
Chodorowska G: Plasma concentrations of IFN-gamma and TNF-alpha in psoriatic patients before and after local treatment with dithranol
Short duration (minutes) therapy with dithranol
for psoriasis: a new out patient regimen Br J Dermatol 1982;106:135-9.