disulfide bridge

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Related to disulfide bridge: Sulfur bridges


1. a fixed partial denture; see illustration.
A bridge unit serves to restore a functional unit by replacing one or more missing teeth. A fixed bridge consists of abutment and pontic teeth splinted together. From Darby and Walsh, 1995.
2. a protoplasmic structure uniting adjacent elements of a cell, similar in plants and animals.
conjugative bridge in bacterial conjugation, a connection formed between two bacterial cells by the attachment of an F pilus from an F+ cell to an F cell.
disulfide bridge disulfide bond.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

di·sul·fide bridge

1. a disulfide linkage between two cysteinyl residues in a polypeptide or oligopeptide or in a protein;
2. any disulfide linkage between any thiol-containing moieties of a larger molecule.
Synonym(s): cystine bridge
Farlex Partner Medical Dictionary © Farlex 2012


1. The upper part of the external nose formed by the junction of the nasal bones.
2. The curved part of a pair of eyeglasses that rests on the bridge of the nose.
3. A narrow band of tissue.
4. A cast dental restoration that replaces missing teeth. The restoration is usually made of gold alloy, with or without a porcelain exterior, and is attached to adjacent or abutment teeth for support.
4. The use of a short-acting drug when treatment with a longer-acting drug must be temporarily interrupted or during the initiation of the long-acting drug before it reaches full therapeutic effectiveness.

Patient care

Bridging is commonly used for perioperative anticoagulation. In patients who have atrial fibrillation or a history of blood clotting, warfarin, which has a relatively long half-life, is withheld several days before surgery. The bridge consists of the administration of low-molecular-weight heparins (LMWHs), which have a shorter half-life, until about 12 hr before the procedure in order to prevent clotting. At a safe time after the operation, LMWHs are reinstituted until warfarin reaches therapeutic levels, e.g., an international normalized ratio of 2 or more. The duration of bridging therapy varies but is typically between 2 days and 1 week.

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5. An exercise for activating the abdominal and hip extensor muscles. The patient lies on his back with knees flexed and feet flat against a horizontal surface, such as a floor, bed, or plinth (treatment table). The patient then lifts his hips while his feet, shoulders, and head maintain contact with the surface. Bridging is often recommended as part of preprosthetic training for patients with transtibial or transfemoral lower extremity amputations. See: illustration


Bridging should always be performed while the prosthesis is removed.

disulfide bridge

Disulfide bond.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
This confirmed structural similarity among products because of the content of buried thiol substituents, coming from nonbonded or broken disulfide bridges [28], revealing the same susceptibility towards degradation (Tables 2 and 3).
Quantitation of buried thiol substituents that come from broken and unpaired disulfide bridges or the total cysteine content within denatured and denatured-reduced Rituximab products, respectively, was suggested from structural analysis by CD spectra.
Linear Discriminant Analysis to Detect Disulfide Bridges
A pattern-recognition approach is also used to automatically detect disulfide bridges in electron density maps (Ioerger 2005).
Mechanisms by which SPINK1 could exert alternative functions were suggested by its structural similarities with epidermal growth factor (EGF): a 50% sequence homology, a molecular size of approximately 6 kDa, and the presence of 3 intrachain disulfide bridges (2).
colt) is the expression of complex proteins with multiple disulfide bridges. In this study the combination of two distinct strategies, manipulated cytoplasm and native periplasm, was applied to produce the functional full length tPA enzyme in E.
coli is the expression of complex proteins with multiple disulfide bridges. Among the several factors affecting the efficiency of such complex proteins production (6-9), the reducing environment of cytoplasm seems to play a key role in improper folding of such high disulfide bonded proteins.
Then, more polymer layers are added and then cross-linked by disulfide bridges into a gel by means of a specially developed, very gentle cross-linking reaction.
Brazzein's rigidity originates from four links called disulfide bridges that lock in the protein's three-dimensional shape.
Inadequate disulfide bond generation: Disulfide bridges stabilize protein structure but can be a challenge to correctly form and maintain.
Also, HLA-G can exist as multimers by forming disulfide bridges through the Cys42 (24).