distal renal tubular acidosis

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Related to distal renal tubular acidosis: proximal renal tubular acidosis

distal renal tubular acidosis (RTA)

an abnormal condition characterized by excessive acid accumulation and bicarbonate excretion. It is caused by the inability of the kidney's distal tubules to secrete hydrogen ions, thus decreasing the excretion of titratable acids and ammonium and increasing the urinary loss of potassium and bicarbonate. The condition may cause hypercalciuria and the formation of kidney stones. Treatment is the same as for renal tubular acidosis. Primary distal RTA occurs mostly in females, adolescents, older children, and young adults. It may occur sporadically or result from hereditary defects. Secondary distal RTA is associated with numerous disorders, such as cirrhosis of the liver, malnutrition, starvation, and various genetic abnormalities. Compare proximal renal tubular acidosis.
References in periodicals archive ?
Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
Prevalence of distal renal tubular acidosis in primary Sjogren's syndrome.
Prevention of recurrent calcium stone formation with potassium citrate therapy in patients with distal renal tubular acidosis.
Distal renal tubular acidosis with severe bony deformities and multiple fractures.
In conclusion, distal renal tubular acidosis can be the first manifestation of SLE, preceding other symptoms by a few years.
Flaccid paresis due to distal renal tubular acidosis preceding systemic lupus erythematosus.

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