disseminated intravascular coagulopathy

disseminated intravascular coagulopathy

Hematology An acquired bleeding diathesis with a generally bad outcome in which the balance between coagulation and fibrinolysis tips toward the former; DIC is characterized by accelerated platelet consumption with coagulation factor depletion–↑ PT, ↑ PTT and stimulation of fibrinolysis–generation of fibrin split products Etiology Severe sepsis–30-65% of DIC is caused by infection, extensive burns, trauma, retained dead fetus, heat stroke, mismatched blood, metastatic CA, leukemia Clinical forms Fast DIC–acute, fulminant, uncompensated consumptive coagulopathy with severe bleeding, and ecchymosis due to abruptio placentae, septic abortion, amniotic fluid embolism, toxemia, malignancy, massive tissue injury–eg burns, surgery, trauma, infections, gram-negative sepsis, meningococcemia, RMSF, incompatible blood; 'fast' DIC requires replacement of deficient or consumed factors Slow DIC Due to chronic compensated illness, with few overt signs of bleeding; clinical picture is painted by thrombosis, microcirculatory ischemia, end-organ infarction, due to acute promyelocytic leukemia, coagulation factor transfusion, CA of pancreas, prostate, lung, stomach, aortic aneurysm, cocaine, IMAOs, giant hemangioma–Kasabach-Merritt syndrome, liver disease, vasculitis, chronic and/or low-grade infections–eg, histoplasmosis, aspergillosis, malaria, obstetrics,–eg, hemolysis, eclampsia, dead fetus, infection, hypoxia, acidosis, respiratory distress; 'slow' DIC may respond to heparinization Lab ↑ PT, aPTT, FDPs, fibrinopeptide A; ↓ fibrinogen, prothrombin, platelets, factor V, factor VIII, antithrombin III, plasminogen, ↓ factors VII, IX, X, XI
References in periodicals archive ?
We present herein a case of HLH in a premature infant presenting with disseminated intravascular coagulopathy (DIC) and liver failure.
Despite appropriate therapy, fever persisted with splenomegaly and disseminated intravascular coagulopathy, and laboratory findings and bone marrow biopsy compatible with HLH.
The most dangerous thing that is often overlooked, even by some of the physicians that treat these on a regular basis, is localized intravascular coagulopathy, which if left untreated can progress to fulminant disseminated intravascular coagulopathy," he said.
fever, anorexia, weight loss, depression, bilateral epistaxis, edema and erythema of scrotum, disseminated intravascular coagulopathy and presence of tick infestation in five dogs and in one dog unilateral epistaxis were observed.
Febrile illness and disseminated intravascular coagulopathy were most common complications observed after obstetric hysterectomy.
One patient developed pancreatitis, and another one disseminated intravascular coagulopathy.
We report a case of a 25-year-old lady who presented to our hospital with Guillain-BarrACopyright Syndrome with the subsequent development of refractory fungaemia multi-organ failure and disseminated intravascular coagulopathy.
Severe theophylline intoxication, rhabdomyolysis, disseminated intravascular coagulopathy and death: case report.
Recombinant factor VIIa after amniotic fluid embolism and disseminated intravascular coagulopathy.
The woman was diagnosed with sepsis, multi-system organ failure, disseminated intravascular coagulopathy, and respiratory dependence.
In patients presenting with thrombocytopenia, diagnosis of ITP is made by exclusion of conditions that may cause thrombocytopenia, which include: drug use (generally heparin, alcohol, quinine/quinidine, sulphonamides), bacterial infections, viral infections (HIV, hepatitis, cytomegalovirus, Epstein-Barr virus), rickettsia infections, mycoplasma infections, lymphoproliferative diseases (chronic lymphocytic leukemia, large granular lymphocytic leukemia, lymphoma), autoimmune diseases (especially systemic lupus erythematosus, antiphospholipid antibody (APA) syndrome), disseminated intravascular coagulopathy, hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, preeclampsia/eclampsia, HELLP syndrome, gestational thrombocytopenia, and hypersplenism.
For example, cryoprecipitate contains factors VIII and XIII, fibrinogen, fibronectin and von Willebrand's factor and can be used in disseminated intravascular coagulopathy, a condition common in the critically ill characterised by abnormal clotting within the blood vessels, that may participate in the development of multiple organ failure and lead to death (Contreras et al 1992, Botha & Taylor 2003).

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