In a series of 7 cases of disseminated histoplasmosis
in HIV/AIDS patients from south Florida, 5 patients had no relevant travel history (25).
Finally, doctors diagnosed her with Humira-induced disseminated histoplasmosis
, a severe, life-threatening infection.
Fatal reactive hemophagocytosis related to disseminated histoplasmosis
with endocarditis: an unusual case diagnosed at autopsy.
Two SAEs of focused interest were reported -- a culture-negative septic arthritis considered probably related to study drug and a fatal disseminated histoplasmosis
and retroperitoneal hemorrhage considered not related to study agent.
His past medical history was significant for a diagnosis of HIV with progression to AIDS for 7 years and was complicated by infections with disseminated histoplasmosis
24 months prior to presentation and Mycobacterium avium complex 18 months prior to presentation.
Extrapulmonary tuberculosis masking disseminated histoplasmosis
The following case presentation describes a patient with a history of chronic hepatitis C, cryoglobulinemia, renal failure and Staphylococcus aureus perinephric abscess and bacteremia, who, at autopsy, was found to have disseminated histoplasmosis
with fungal endocarditis and RHS.
For diagnosis of AIDS in a patient with disseminated histoplasmosis
The patients subsequently die of probable disseminated histoplasmosis
(DH), and the fungal infection might finally be detected in postmortem tissue samples (5).
The possibility of disseminated histoplasmosis
was considered, but the subsequent workup included negative fungal culture results from the biopsies (ie, no fungi growth), normal findings from a chest roentgenogram, and a urinary antigen test result that was negative for Histoplasma.
The prognosis of disseminated infection in this context is close to the 20% mortality rate reported for disseminated histoplasmosis
due to variety capsulatum among AIDS patients (21), but the few number of cases does not allow us to extrapolate the mortality rate related to variety duboisii.
arises usually when the immune system is compromised, specific T cell mediated immunity.