The burden of HIV-related mycosis worldwide is estimated to account, per year, for more than 950,000 cases of cryptococcosis, 400,000 cases of PJP, and 300,000 of disseminated histoplasmosis
10) While rare cases of fungal endophthalmitis have been seen in patients with disseminated histoplasmosis
, the association of Histoplasma capsulatum with POHS is presumptive and based primarily on epidemiologic grounds.
To the Editor: Progressive disseminated histoplasmosis
(PDH) of infancy occurs most commonly in previously healthy infants <1 year of age, typically after exposure to a large fungal inoculum (1).
Markedly elevated serum lactate dehydrogenase levels are a clue to the diagnosis of disseminated histoplasmosis
in patients with AIDS.
one case of disseminated histoplasmosis
, a single case of pulmonary histoplasmosis , one case of mediastinal lymphadenopathy revealing histoplasmosis , one case of histoplasmosis-induced brain abscess and one case of extrapulmonary histoplasmosis , one case of histoplasmosis-related pleural effusion .
with lesions restricted to the larynx in a patient with AIDS.
is a rare form of the infection that can be fatal, even if properly treated.
Most patients with disseminated histoplasmosis
have underlying conditions that impair their ability to defend against intracellular pathogens.
Fatal reactive hemophagocytosis related to disseminated histoplasmosis
with endocarditis: an unusual case diagnosed at autopsy.
Progressive disseminated histoplasmosis
often occurs in immunocompromised patients.
Establishing the burden of disseminated histoplasmosis
In the case of fungal infections, two cases of disseminated histoplasmosis
were diagnosed on histological examination of a lymph node biopsy and a skin biopsy respectively.