Despite perceived advances in antifungal therapies, invasive and, moreover,
disseminated aspergillosis remain devastating opporhinistic infections.
Central nervous system (CNS) is the most prevalent site for
disseminated aspergillosis. Such patients usually present with lethargy, coma, or focal neurological signs (8).
There is also a condition called
disseminated aspergillosis, which is very rare in dogs.
The echinocandins have no hepatotoxicity or nephrotoxicity and are effective in animal models of esophageal candidiasis, disseminated candidiasis, Pneumocystis carinii, and invasive pulmonary and
disseminated aspergillosis. Oral, esophageal, and pharyngeal candidiasis and acute invasive aspergillosis have responded well in clinical trials.
The echinocandins demonstrate a high degree of efficacy in animal models of esophageal candidiasis, disseminated candidiasis, Pneumocystis carinii, and invasive pulmonary and
disseminated aspergillosis.
