disintegrins

A family of snake venom anticoagulants that bind to INTEGRINS on the surface of platelets and cells, preventing their interaction with the extracellular matrix and with other cells. They inhibit tumour growth and angiogenesis and may have value in the treatment of cancer.

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Helicobacter pylori and gastritis: the role of extracellular matrix met al.loproteases, their inhibitors, and the disintegrins and met al.loproteases--a systematic literature review.

Morfologia y Repercusiones Diagnostico-Terapeuticas de las Lesiones Preneoplasicas Gastricas/Morphology and Diagnostic Determinants of Gastric Precancerous Conditions

These cells are able to produce and secrete mediator molecules such as cytokines, chemokines, growth-factors, enzymes, and disintegrins, which activate endothelial cells, proliferation of smooth muscle cells, and lesion progression, and contribute to the weakening of a vulnerable plaque by matrix degradation of its fibrous cap.

Comparative Study of Protein Expression Levels of Five Plaque Biomarkers and Relation with Carotid Plaque Type Classification in Patients after Carotid Endarterectomy

Liang et al., "Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-kB signaling," Inflammation Research, vol.

Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway

In addition, two separate disintegrins and metalloproteinases with thrombospondin motifs (ADAMTS-1 and ADAMTS-4) are highly expressed in an SIV model [82].

Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

L-Selectins are cleaved from the cell surface by the action of ADAM17 (disintegrins and metalloproteinase 17) or TACE (TNF-[alpha] converting enzyme), a process known as "shedding," which may dramatically regulate migratory cell behaviour [35].

Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy

Such cytokines induce the production of matrix metalloproteinases (MMPs), disintegrins, and metalloproteinases with thrombospondin motifs (ADAMTS) and inducible nitric oxide synthase (iNOS) in the joints, ultimately leading to cartilage degradation [8].

Interleukin-17 Can Induce Osteoarthritis in Rabbit Knee Joints Similar to Hulth's Method

In particular, common rattlesnake (Crotalus and Sistrurus genera) venom components include metalloproteinases, serine proteases, phospholipases [A.sub.2] (PL[A.sub.2]s), L-amino acid oxidases (LAAOs), Cysteine-Rich Secretory Proteins (CRISPs), C-type lectin-like, disintegrins and vasoactive peptides [5,6,10].

Morulustatin, una desintegrina que inhibe la agregacion plaquetaria inducida por ADP, aislada de la serpiente de cascabel (Crotalus lepidus Morulus) de la roca de Tamaulipas, Mexico

Epigallocatechin-3-gallate (EGCG), a GA derivative, was found to inhibit degradation of human cartilage proteoglycan and type II collagen, and selectively inhibits ADAMTS-1, ADAMTS-4, and ADAMTS-5 (disintegrins and metalloproteinases with thrombospondin motifs) (37,38).

Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro

Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.

Differential Expression Patterns of a Disintegrin and Metalloproteinase With Thrombospondin Motifs (ADAMTS) -1, -4, -5, and -14 in Human Placenta and Gestational Trophoblastic Diseases

Corticosteroids [1-6] antiproliferative agents (5-fluorouracil and other fluoropyrimidines, taxol, doxorubicin, mycophenolate mofetil..., alone or in combination or with different delivery systems) [3-12], systemic, periocular, intraocular steroidal, and nonsteroidal anti-inflammatory agents [5,13-16], colchicine [8], daunomycin [8], tissue plasminogen activator [17], heparin [12,18-20], interferon-gamma [21,22], calcium channel blockers [23], prolyl and lysyl hydroxylase inhibitors [19,24-26], retinoic acid [27,28], alpha-tocopherol [29-31], disintegrins [32], siRNA-PKCa [33]...

In vitro vitamin [K.sub.3] effect on conjunctival fibroblast migration and proliferation

Cobra venom is a complex of many proteins, peptides, and enzymes that contains cardiotoxin, neurotoxin, PLA2, cytotoxin, nerve growth factor, lectins, and disintegrins and exhibits a variety of pharmacological and toxic activities including anti-inflammatory, bactericidal, analgesic, anticancer, platelet-aggregation inhibition, and anticoagulant, myotoxic, neurotoxic, hypotension, and haemolytic actions [9, 10].

Ameliorating adriamycin-induced chronic kidney disease in rats by orally administrated cardiotoxin from Naja naja atra venom

(2001) purified novel disintegrins, the platelet aggregation inhibitors pyramidin A and B from the venom of E.