disintegrins

disintegrins

A family of snake venom anticoagulants that bind to INTEGRINS on the surface of platelets and cells, preventing their interaction with the extracellular matrix and with other cells. They inhibit tumour growth and angiogenesis and may have value in the treatment of cancer.
References in periodicals archive ?
Helicobacter pylori and gastritis: the role of extracellular matrix met al.loproteases, their inhibitors, and the disintegrins and met al.loproteases--a systematic literature review.
These cells are able to produce and secrete mediator molecules such as cytokines, chemokines, growth-factors, enzymes, and disintegrins, which activate endothelial cells, proliferation of smooth muscle cells, and lesion progression, and contribute to the weakening of a vulnerable plaque by matrix degradation of its fibrous cap.
Liang et al., "Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-kB signaling," Inflammation Research, vol.
In addition, two separate disintegrins and metalloproteinases with thrombospondin motifs (ADAMTS-1 and ADAMTS-4) are highly expressed in an SIV model [82].
L-Selectins are cleaved from the cell surface by the action of ADAM17 (disintegrins and metalloproteinase 17) or TACE (TNF-[alpha] converting enzyme), a process known as "shedding," which may dramatically regulate migratory cell behaviour [35].
Such cytokines induce the production of matrix metalloproteinases (MMPs), disintegrins, and metalloproteinases with thrombospondin motifs (ADAMTS) and inducible nitric oxide synthase (iNOS) in the joints, ultimately leading to cartilage degradation [8].
In particular, common rattlesnake (Crotalus and Sistrurus genera) venom components include metalloproteinases, serine proteases, phospholipases [A.sub.2] (PL[A.sub.2]s), L-amino acid oxidases (LAAOs), Cysteine-Rich Secretory Proteins (CRISPs), C-type lectin-like, disintegrins and vasoactive peptides [5,6,10].
Epigallocatechin-3-gallate (EGCG), a GA derivative, was found to inhibit degradation of human cartilage proteoglycan and type II collagen, and selectively inhibits ADAMTS-1, ADAMTS-4, and ADAMTS-5 (disintegrins and metalloproteinases with thrombospondin motifs) (37,38).
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
Corticosteroids [1-6] antiproliferative agents (5-fluorouracil and other fluoropyrimidines, taxol, doxorubicin, mycophenolate mofetil..., alone or in combination or with different delivery systems) [3-12], systemic, periocular, intraocular steroidal, and nonsteroidal anti-inflammatory agents [5,13-16], colchicine [8], daunomycin [8], tissue plasminogen activator [17], heparin [12,18-20], interferon-gamma [21,22], calcium channel blockers [23], prolyl and lysyl hydroxylase inhibitors [19,24-26], retinoic acid [27,28], alpha-tocopherol [29-31], disintegrins [32], siRNA-PKCa [33]...
Cobra venom is a complex of many proteins, peptides, and enzymes that contains cardiotoxin, neurotoxin, PLA2, cytotoxin, nerve growth factor, lectins, and disintegrins and exhibits a variety of pharmacological and toxic activities including anti-inflammatory, bactericidal, analgesic, anticancer, platelet-aggregation inhibition, and anticoagulant, myotoxic, neurotoxic, hypotension, and haemolytic actions [9, 10].
(2001) purified novel disintegrins, the platelet aggregation inhibitors pyramidin A and B from the venom of E.

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