Helicobacter pylori and gastritis: the role of extracellular matrix met al.loproteases, their inhibitors, and the disintegrins
and met al.loproteases--a systematic literature review.
These cells are able to produce and secrete mediator molecules such as cytokines, chemokines, growth-factors, enzymes, and disintegrins
, which activate endothelial cells, proliferation of smooth muscle cells, and lesion progression, and contribute to the weakening of a vulnerable plaque by matrix degradation of its fibrous cap.
Liang et al., "Regulation of a disintegrins
and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-kB signaling," Inflammation Research, vol.
In addition, two separate disintegrins
and metalloproteinases with thrombospondin motifs (ADAMTS-1 and ADAMTS-4) are highly expressed in an SIV model .
L-Selectins are cleaved from the cell surface by the action of ADAM17 (disintegrins
and metalloproteinase 17) or TACE (TNF-[alpha] converting enzyme), a process known as "shedding," which may dramatically regulate migratory cell behaviour .
Such cytokines induce the production of matrix metalloproteinases (MMPs), disintegrins
, and metalloproteinases with thrombospondin motifs (ADAMTS) and inducible nitric oxide synthase (iNOS) in the joints, ultimately leading to cartilage degradation .
In particular, common rattlesnake (Crotalus and Sistrurus genera) venom components include metalloproteinases, serine proteases, phospholipases [A.sub.2] (PL[A.sub.2]s), L-amino acid oxidases (LAAOs), Cysteine-Rich Secretory Proteins (CRISPs), C-type lectin-like, disintegrins
and vasoactive peptides [5,6,10].
Epigallocatechin-3-gallate (EGCG), a GA derivative, was found to inhibit degradation of human cartilage proteoglycan and type II collagen, and selectively inhibits ADAMTS-1, ADAMTS-4, and ADAMTS-5 (disintegrins
and metalloproteinases with thrombospondin motifs) (37,38).
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins
and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
Corticosteroids [1-6] antiproliferative agents (5-fluorouracil and other fluoropyrimidines, taxol, doxorubicin, mycophenolate mofetil..., alone or in combination or with different delivery systems) [3-12], systemic, periocular, intraocular steroidal, and nonsteroidal anti-inflammatory agents [5,13-16], colchicine , daunomycin , tissue plasminogen activator , heparin [12,18-20], interferon-gamma [21,22], calcium channel blockers , prolyl and lysyl hydroxylase inhibitors [19,24-26], retinoic acid [27,28], alpha-tocopherol [29-31], disintegrins
, siRNA-PKCa ...
Cobra venom is a complex of many proteins, peptides, and enzymes that contains cardiotoxin, neurotoxin, PLA2, cytotoxin, nerve growth factor, lectins, and disintegrins
and exhibits a variety of pharmacological and toxic activities including anti-inflammatory, bactericidal, analgesic, anticancer, platelet-aggregation inhibition, and anticoagulant, myotoxic, neurotoxic, hypotension, and haemolytic actions [9, 10].
(2001) purified novel disintegrins
, the platelet aggregation inhibitors pyramidin A and B from the venom of E.