disintegrins

disintegrins

A family of snake venom anticoagulants that bind to INTEGRINS on the surface of platelets and cells, preventing their interaction with the extracellular matrix and with other cells. They inhibit tumour growth and angiogenesis and may have value in the treatment of cancer.
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2]s), L-amino acid oxidases (LAAOs), Cysteine-Rich Secretory Proteins (CRISPs), C-type lectin-like, disintegrins and vasoactive peptides [5,6,10].
some metalloproteinases, serine proteases and disintegrins isolated from snake venoms have served as a basis for the manufacture of drugs designed for the diagnosis and treatment of cardiovascular and cerebrovascular disorders.
Disintegrins are peptides rich in cysteines that contain in their structure a sequence of amino acids located at the tip of a flexible hairpin loop of type RGD, KGD, MLD, KTS, ECD, VGD, MGD and WGD, which recognize integrin receptors [15].
2001) purified novel disintegrins, the platelet aggregation inhibitors pyramidin A and B from the venom of E.
2001 Comparative biochemistry of disintegrins isolated from snake venom: consideration of the taxonomy and geographical distribution of snakes in the genus Echis.
Using a combination of gel filtration, anion-exchange chromatography, and reverse-phase high performance liquid chromatography, we isolated an acidic protein which shows a single chain composition, with a molecular mass of ~8 kDa, estimated by SDS-polyacrylamide gel electrophoresis, Its N-terminal sequence has high similarity to disintegrins isolated from different snake venoms, which are known to bind to cellular integrins such as the GPIlb/IIIa fibrinogen receptor on platelets.
This partial sequence is compared to that of other disintegrins in Table 1.
Snake venoms may contain a variety of components with the ability to inhibit platelet aggregation, which, to date, correspond to one of the following types: disintegrins, [alfa]-fibrinogenases, 5'-nucleotidases, and phospholipases [A.
Measurement of glycoprotein IIb/IIIa blockade by flow cytometry with fluorescein isothiocyanate-conjugated crotavirin, a member of disintegrins.
Recently, a new molecular substance has garnered much interest, namely, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS).
Abbreviation: ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs (original magnifications X200 [A, C, D, E, and F] and X400 [inset and B]).
In the present study, we report elevated gene expression of a disintegrin and metalloprotease (ADAM) in the paretic leg muscle after stroke.

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