The FDA-approved disintegrant
for pharmaceuticals, CMC improves the dissolving capability of medicines, thereby enhancing their meant effect, which in turn has been driving CMC demand in the pharmaceutical industry.
Pharmaceutical excipients market by functionality is segmented as preservatives, solvent, binders & adhesives, fillers & diluents, suspending agent, coatings, solubilizer, disintegrant
, colorant, flavoring & sweeteners, lubricants & glidants, and others.
Films having PVA and PVP K30 as a disintegrant
showed more elongation as compared to all other formulations because of combination of most flexible polymers.
(15) Incorporating a powerful disintegrant
in formulating tablets would contribute to the bioresponse of the tablets.
- Northbrook, Illinois-based business to business (B2B) research provider MarketsandMarkets has published a market research report entitled "Pharmaceutical Excipients Market by Type (Organic chemical (Carbohydrate, Petrochemical), Inorganic chemical), Functionality (Filler, Coating, Disintegrant
, Binder), Formulation (Tablet, Capsule, Topical, Parenteral) -- Global Forecast to 2023," the company said.
This includes pharmaceutical-grade salt used in intravenous solutions and liquid medicines; high purity carboxymethyl cellulose used as a super disintegrant
in pharmaceutical tablets; and organic peroxides and chlorine-based intermediates used as key reagents in making of some of the largest blockbuster drugs.
Even though formulation F1 contained a superdisintegrant as well as microcrystalline cellulose, with expected enhanced disintegrant
properties, a release of 39.0% hydrocortisone in 30 min was observed.
The rapid disintegration time exhibited by all the brands might be due to type and amount of disintegrant
used in the formulation.
Sriamornsak, "Effect of drying technique and disintegrant
on physical properties and drug release behavior of microcrystalline cellulose-based pellets prepared by extrusion/spheronization," Chemical Engineering Research and Design, vol.
Bisoprolol fumarate + Initial 2 weeks 4 weeks 8 weeks Diluent 1 / / / / Diluent 2 (calcium / 0.04% 0.05% 0.08% hydrogen phosphate) Glidant / / / / Disintegrant
/ / / / Filler / / / / TABLE 2: Increase of the amount of RRT 0.95 before and after thermal degradation of drug product.
Abstract: The aim of this study is to investigate the physicochemical and disintegrant
properties of a cellulose obtained from sugarcane scrapings and bagasse.
Hard candy gum drops Paper/board/corrugating Pigment retention on paper (wet-end addition), as surface sizing agent coating Brewing as adjunct Textile/warp sizing Text finishing agents to add weight, smoothness and stiffness Pharmaceuticals Cosmetics: tooth paste, body cream or lotion Pharmaceutical tablets; binder, filler, disintegrant
Body powders Building pots Binder for foundries Agriculture Soil conditioners Adhesives Corrugated boards paper bag Guming applications Crude oil mining Oil drilling mud Briquetting Domestic and industrial heating Packaging Plastics High temperature stable hybrid nylon e.g., meat roasting nylon; Edible films Preparation of surgeon gloves Table 4.