Third, we recognized that it is not the same to be a woman living with HIV in a discordant couple
than a woman who is the partner of a man who is HIV+.
To be included in the study, subjects must have been enrolled in the heterosexual discordant couple
cohort study at the PSF from its inception in Lusaka, Zambia, in January 1994 to the time of the proposed study--July 1998.
When the female partner is HIV-infected and the male partner is not, a discordant couple
can undergo autologous sperm intrauterine inseminations to achieve conception without placing the man at risk for infection.
generally) why would a discordant couple
use PrEPs when antiretrovirals with condoms pretty much do the trick?
Negative people enjoy sex, but the discordant couple
does not enjoy sex because of a condom.
A subsequent study using DHS data from 18 countries, the majority in sub-Saharan Africa, found that discordant couple
preferences are common with men often preferring more children and shorter birth intervals than their wives; in 10 to 26% of couples, there was disagreement on desire for additional children (6).
Based on this study, for discordant couples
in which the man is treated with HAART, the postulated risk for transmission to a female partner during condomless intercourse would be 0.
The correct and consistent use of condoms has proven to be effective in preventing HIV transmission between discordant couples
6 In a Ugandan cohort of HIV discordant couples
, the probability of HIV transmission per coital act increased 2-fold in the presence of genital ulcer disease (GUD), whereas there was no increased risk of transmission for non-ulcer syndromes.
Sexual behavior of HIV discordant couples
after HIV counseling and testing.
In the HIV Prevention Trials Network 052 study of discordant couples
, for instance, early antiretroviral therapy in an infected partner not only reduced the number of clinical events; it almost completely blocked sexual transmission of the virus to an HIV-negative partner (N.
There is a clear transmission-prevention benefit in discordant couples
and there are accumulating data in the community setting.