Discordant UIP | definition of discordant UIP by Medical dictionary
discordant UIP Discordant usual interstitial pneumonia. A “form” of usual interstitial pneumonia which is diagnosed based on differences in histology from multilobar surgical lung biopsies for suspected idiopathic pulmonary fibrosis (IPF), where one or more biopsies has UIP and one or more biopsies has non-specific interstitial pneumonia (NSIP). Discordant UIP occurs in about one-fourth of patients with IPF, and has a survival closer to concordant UIP (i.e., less favourable) than to concordant NSIP.
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References in periodicals archive
Others have identified that the prognosis of cases with one lobe showing UIP and another lobe showing NSIP (discordant UIP
) had a prognosis that was worse than NSIP alone and concordant UIP.
(14,15) The histologic coexistence of the NSIP pattern (NSIP-P) and the UIP pattern is not well-established, although some studies have documented coexisting UIP and NSIP patterns (so-called discordant UIP
) as well as potential progression from NSIP to combined NSIP-UIP.