Of the 335 reported discordances, glass was the preferred diagnostic modality in 286 cases (85%).
Most discordances (169 cases) fell into the category of B3, areas of appreciable diagnostic difficulty and recognized interobserver variation, such as the difference between 2 adjacent grades of a malignant condition.
However, the most common aetiology responsible for phenotype discordance between MZ twins is the involvement of epigenetic mechanisms.
Alternatively, the possibility of the discordance of the female MZ twins resulting from the differential expression of their maternal and paternal chromosomes is not novel.
In 6 cervical cases, there was a slight
discordance in the grading of dysplasia for the low-grade category, between cervical intraepithelial neoplasia grade 1 (CIN1) and condyloma (cases 5-10); and in 2 cases,
discordance concerned the high-grade lesions (CIN2 versus CIN3/carcinoma in situ; cases 3 and 4).
First, it is a cross-sectional study and therefore cannot predict the development of coronary artery disease, nor can it predict the effects of cholesterol-lowering therapy in the concordance and
discordance groups.
Our study focused on
discordances in distinguishing NSCLC from SCLC because pathologists have not been asked before to further classify the lung cancer type in cytology specimens.
The finding that
discordance is more often explainable by failure of the liver biopsy than by errors in the markers might be considered as evidence that fibrosis markers are more accurate than biopsy.
The aims of this study were (a) to prospectively assess the quality of biopsy in a large hospital-based cohort; (b) to prospectively assess the prevalence and the factors associated with significant
discordances between liver biopsy estimates and FT-AT estimates; (c) to attribute the cause of
discordances to biopsy or to FT-AT; and (d) to detect possible causes of failures attributable to FT-AT in a large community-based population by analyzing the distribution of the six components of FT-AT.
Discordances between cTnT and cTnI were observed in 6 of a total of 18 samples in sample I and persisted in 5 of these in sample II at either cutoff value.
