Using these follow-up modalities as the gold standard,
discordance rates were calculated for PGFNAs and UGFNAs.
A deficit in one of these aspects can create a discordant assessment (i.e., iatrogenic
discordance).
However, the most common aetiology responsible for phenotype
discordance between MZ twins is the involvement of epigenetic mechanisms.
The majority of recorded
discordances occurred in gastrointes tinal, skin, genitourinary, and gynecologic cases.
First, it is a cross-sectional study and therefore cannot predict the development of coronary artery disease, nor can it predict the effects of cholesterol-lowering therapy in the concordance and
discordance groups.
In 6 cervical cases, there was a slight
discordance in the grading of dysplasia for the low-grade category, between cervical intraepithelial neoplasia grade 1 (CIN1) and condyloma (cases 5-10); and in 2 cases,
discordance concerned the high-grade lesions (CIN2 versus CIN3/carcinoma in situ; cases 3 and 4).
Our study focused on
discordances in distinguishing NSCLC from SCLC because pathologists have not been asked before to further classify the lung cancer type in cytology specimens.
The aims of this study were (a) to prospectively assess the quality of biopsy in a large hospital-based cohort; (b) to prospectively assess the prevalence and the factors associated with significant
discordances between liver biopsy estimates and FT-AT estimates; (c) to attribute the cause of
discordances to biopsy or to FT-AT; and (d) to detect possible causes of failures attributable to FT-AT in a large community-based population by analyzing the distribution of the six components of FT-AT.
Discordances between cTnT and cTnI were observed in 6 of a total of 18 samples in sample I and persisted in 5 of these in sample II at either cutoff value.
Our objective was to determine the rate and degree of growth
discordance in pregnancy with dichorionic twins conceived by IVF compared to those conceived spontaneously and to assess association of the growth
discordance with adverse perinatal outcome.
The use of a validated image-analysis system has been shown to substantially reduce interpathologist
discordance in interpreting IHC assay results (9).
The finding that
discordance is more often explainable by failure of the liver biopsy than by errors in the markers might be considered as evidence that fibrosis markers are more accurate than biopsy.
